有既往疾病的习惯性短睡眠者患长新冠的风险更高。

Habitual short sleepers with pre-existing medical conditions are at higher risk of Long COVID.

机构信息

Department of Anesthesia and Pain Management, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.

SleepWell Research Program, Faculty of Medicine, University of Helsinki, Orton Orthopaedics Hospital, Helsinki, Finland.

出版信息

J Clin Sleep Med. 2024 Jan 1;20(1):111-119. doi: 10.5664/jcsm.10818.

DOI:10.5664/jcsm.10818

PMID:37858285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10758549/

Abstract

STUDY OBJECTIVES

Preliminary evidence suggests that the risk of Long COVID is higher among people with pre-existing medical conditions. Based on its proven adjuvant role in immunity, habitual sleep duration may alter the risk of developing Long COVID. The objective of this study was to determine whether the odds of Long COVID are higher among those with pre-existing medical conditions, and whether the strength of this association varies by habitual sleep duration.

METHODS

Using data from 13,461 respondents from 16 countries who participated in the 2021 survey-based International COVID Sleep Study II (ICOSS II), we studied the associations between habitual sleep duration, pre-existing medical conditions, and Long COVID.

RESULTS

Of 2,508 individuals who had COVID-19, 61% reported at least 1 Long COVID symptom. Multivariable logistic regression analysis showed that the risk of having Long COVID was 1.8-fold higher for average-length sleepers (6-9 h/night) with pre-existing medical conditions compared with those without pre-existing medical conditions (adjusted odds ratio [aOR] 1.84 [1.18-2.90]; = .008). The risk of Long COVID was 3-fold higher for short sleepers with pre-existing medical conditions (aOR 2.95 [1.04-8.4]; = .043) and not significantly higher for long sleepers with pre-existing conditions (aOR 2.11 [0.93-4.77]; = .073) compared with average-length sleepers without pre-existing conditions.

CONCLUSIONS

Habitual short nighttime sleep duration exacerbated the risk of Long COVID in individuals with pre-existing conditions. Restoring nighttime sleep to average duration represents a potentially modifiable behavioral factor to lower the odds of Long COVID for at-risk patients.

CITATION

Berezin L, Waseem R, Merikanto I, et al. Habitual short sleepers with pre-existing medical conditions are at higher risk of long COVID. . 2024;20(1):111-119.

摘要

研究目的

初步证据表明，患有基础疾病的人群感染长期新冠的风险更高。基于其在免疫方面已被证实的辅助作用，习惯性的睡眠时间可能会改变感染长期新冠的风险。本研究旨在确定患有基础疾病的人群感染长期新冠的几率是否更高，以及这种关联的强度是否因习惯性睡眠时间而异。

方法

使用来自 16 个国家的 13461 名参与者的 2021 年基于调查的国际新冠睡眠研究 II（ICOSS II）的数据，我们研究了习惯性睡眠时间、基础疾病与长期新冠之间的关联。

结果

在 2508 名患有 COVID-19 的个体中，61%报告至少有 1 种长期新冠症状。多变量逻辑回归分析显示，与无基础疾病的个体相比，有基础疾病且平均睡眠时间为 6-9 小时/夜的个体感染长期新冠的风险高 1.8 倍（调整后的优势比 [aOR] 1.84 [1.18-2.90]； =.008）。有基础疾病且睡眠时间短的个体感染长期新冠的风险高 3 倍（aOR 2.95 [1.04-8.4]； =.043），而有基础疾病且睡眠时间长的个体感染长期新冠的风险无显著增加（aOR 2.11 [0.93-4.77]； =.073），与无基础疾病的平均睡眠时间个体相比。

结论

习惯性的夜间短睡眠时间加剧了有基础疾病个体感染长期新冠的风险。将夜间睡眠时间恢复到平均时长代表了一种潜在可改变的行为因素，可以降低高危患者感染长期新冠的几率。

引文

Berezin L, Waseem R, Merikanto I, et al. Habitual short sleepers with pre-existing medical conditions are at higher risk of long COVID.. 2024;20(1):111-119.