Key Laboratory of Microecology-Immune Regulatory Network and Related Diseases, School of Basic Medicine, Jiamusi University, Jiamusi 154007, Heilongjiang Province, China.
Shanghai Key Laboratory of Forensic Medicine, Key Laboratory of Forensic Science, Ministry of Justice, Shanghai Forensic Service Platform, Academy of Forensic Science, Shanghai 200063, China.
Fa Yi Xue Za Zhi. 2023 Aug 25;39(4):382-387. doi: 10.12116/j.issn.1004-5619.2022.220610.
To study the virtual reality-pattern visual evoked potential (VR-PVEP) P100 waveform characteristics of monocular visual impairment with different impaired degrees under simultaneous binocular perception and monocular stimulations.
A total of 55 young volunteers with normal vision (using decimal recording method, far vision ≥0.8 and near vision ≥0.5) were selected to simulate three groups of monocular refractive visual impairment by interpolation method. The sum of near and far vision ≤0.2 was Group A, the severe visual impairment group; the sum of near and far vision <0.8 was Group B, the moderate visual impairment group; and the sum of near and far vision ≥0.8 was Group C, the mild visual impairment group. The volunteers' binocular normal visions were set as the control group. The VR-PVEP P100 peak times measured by simultaneous binocular perception and monocular stimulation were compared at four spatial frequencies 16×16, 24×24, 32×32 and 64×64.
In Group A, the differences between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at 24×24, 32×32 and 64×64 spatial frequencies were statistically significant (<0.05); and the P100 peak time of normal vision eyes at 64×64 spatial frequency was significantly different from the simulant visual impairment eyes (<0.05). In Group B, the differences between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at 16×16, 24×24 and 64×64 spatial frequencies were statistically significant (<0.05); and the P100 peak time of normal vision eyes at 64×64 spatial frequency was significantly different from the simulant visual impairment eyes (<0.05). In Group C, there was no significant difference between P100 peak times of simulant visual impairment eyes and simultaneous binocular perception at all spatial frequencies (>0.05). There was no significant difference in the P100 peak times measured at all spatial frequencies between simulant visual impairment eyes and simultaneous binocular perception in the control group (>0.05).
VR-PVEP can be used for visual acuity evaluation of patients with severe and moderate monocular visual impairment, which can reflect the visual impairment degree caused by ametropia. VR-PVEP has application value in the objective evaluation of visual function and forensic clinical identification.
研究不同程度单眼视障患者在双眼同时知觉和单眼刺激下虚拟现实-图案视觉诱发电位（VR-PVEP）P100 波形特征。
采用插值法模拟三组单眼屈光性视力障碍志愿者，选择 55 名视力正常的年轻志愿者（十进制记录法，远视力≥0.8，近视力≥0.5），近、远视力之和≤0.2 为 A 组，为严重视力障碍组；近、远视力之和＜0.8 为 B 组，为中度视力障碍组；近、远视力之和≥0.8 为 C 组，为轻度视力障碍组。志愿者双眼正常视力为对照组。比较双眼同时知觉和单眼刺激时四种空间频率（16×16、24×24、32×32 和 64×64）下测量的 VR-PVEP P100 峰潜伏期。
A 组中，24×24、32×32 和 64×64 空间频率下模拟视力障碍眼与双眼同时知觉的 P100 峰潜伏期差异有统计学意义（<0.05）；64×64 空间频率下正常眼的 P100 峰潜伏期与模拟视力障碍眼差异有统计学意义（<0.05）。B 组中，16×16、24×24 和 64×64 空间频率下模拟视力障碍眼与双眼同时知觉的 P100 峰潜伏期差异有统计学意义（<0.05）；64×64 空间频率下正常眼的 P100 峰潜伏期与模拟视力障碍眼差异有统计学意义（<0.05）。C 组中，各空间频率下模拟视力障碍眼与双眼同时知觉的 P100 峰潜伏期差异无统计学意义（>0.05）。对照组各空间频率下模拟视力障碍眼与双眼同时知觉的 P100 峰潜伏期差异无统计学意义（>0.05）。
虚拟现实-图案视觉诱发电位可用于评估严重和中度单眼视力障碍患者的视力，能反映屈光不正引起的视力障碍程度。虚拟现实-图案视觉诱发电位在客观评估视觉功能和法医临床鉴定方面具有应用价值。
