[大鼠原位肝移植。在急性排斥模型中使用环孢素A延长同种异体移植的存活时间]
[Orthotopic liver transplantation in rats. Prolonging of survival time of allotransplants using cyclosporin A in an acute rejection model].
作者信息
Zimmermann F A, White D J, Gokel J M, Calne R Y
出版信息
Chir Forum Exp Klin Forsch. 1979:339-44.
PMID:378595
Abstract
Livers from inbred DA rats were transplanted orthotopically into inbred BN rats. Within 15 days all animals died due to rejection of the transplant. However, when rats were treated with Cyclosporin A (four different regimens) they survived for at least 60 days, even if therapy was withdrawn at day 28. It could be shown that the histologic changes in the graft stood in an inverse relationship to the extent of immunosuppressive therapy.
摘要
将近交系DA大鼠的肝脏原位移植到近交系BN大鼠体内。15天内，所有动物均因移植排斥反应死亡。然而，当用环孢素A（四种不同方案）治疗大鼠时，它们至少存活了60天，即使在第28天停止治疗也是如此。可以证明，移植物中的组织学变化与免疫抑制治疗的程度呈反比关系。
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