Koss M N, Hochholzer L, Langloss J M, Wehunt W D, Lazarus A A, Nichols P W
Pathology. 1986 Jul;18(3):283-8. doi: 10.3109/00313028609059478.
We studied the histological and clinicopathological findings in 42 patients who had lymphomatoid granulomatosis (LYG). In addition to small round lymphocytes, small to intermediate lymphocytes with serpentine nuclei, large immature mononuclear lymphoid cells, abundant histiocytes, and vascular invasion by the cell infiltrate were observed in all cases. Fifty percent of lesions had occasional "atypical" cells with multi-lobed nuclei. Three of four follow-up autopsies showed large cell lymphoma, while one other autopsy and the single repeat biopsy showed increased numbers of large immature mononuclear lymphoid cells. Patients were most frequently men 40-60 yr old who had a history of pulmonary symptoms, such as cough or chest pain, and who showed multiple bilateral lung nodules without hilar adenopathy in the chest x-ray. Thirteen patients (38%) died of disease, 11 of them within 12 mth of initial diagnosis. The presence of neurological signs and symptoms, increased mitoses, or increased numbers of atypical multi-nucleated cells in the initial biopsy were not statistically significant predictors of survival.
我们研究了42例淋巴瘤样肉芽肿病（LYG）患者的组织学和临床病理结果。除小圆形淋巴细胞外，所有病例均观察到核呈蛇形的小至中等大小淋巴细胞、大的未成熟单核淋巴细胞、丰富的组织细胞以及细胞浸润导致的血管侵犯。50%的病变偶尔可见有多叶核的“非典型”细胞。4例随访尸检中有3例显示为大细胞淋巴瘤，而另一例尸检及单次重复活检显示大的未成熟单核淋巴细胞数量增加。患者最常见的是40至60岁有肺部症状（如咳嗽或胸痛）病史的男性，胸部X线显示双侧多发肺结节且无肺门淋巴结肿大。13例患者（38%）死于该病，其中11例在初次诊断后12个月内死亡。初次活检时出现神经体征和症状、有丝分裂增加或非典型多核细胞数量增加并非生存的统计学显著预测因素。
