James W D, Odom R B, Katzenstein A L
Arch Dermatol. 1981 Apr;117(4):196-202.
A review of records of 44 patients who had lymphomatoid granulomatosis (LYG) with skin lesions showed that cutaneous manifestations are protean and generally transient. Subcutaneous or dermal nodules were present in more than 60% of cases. A maculopapular rash or macular erythema was less common, and ulceration was rare. Skin lesions were widely distributed. Frequently, in patients who had early cutaneous involvement with LYG, associated involvement of the nervous system and joints occurred. Findings from laboratory studies were generally inconclusive. Lymphomatoid granulomatosis progressed to lymphoma in 18% of the cases, and death from respiratory failure was common. Theories on the possible cause and the pathogenesis of LYG are presented.
一项对44例患有伴皮肤病变的淋巴瘤样肉芽肿病（LYG）患者记录的回顾显示，皮肤表现多种多样且通常为一过性。超过60%的病例存在皮下或真皮结节。斑丘疹或斑状红斑较少见，溃疡罕见。皮肤病变分布广泛。LYG早期皮肤受累的患者常伴有神经系统和关节受累。实验室检查结果通常无定论。18%的病例中淋巴瘤样肉芽肿病进展为淋巴瘤，呼吸衰竭导致的死亡很常见。文中还介绍了关于LYG可能病因及发病机制的理论。
