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新型冠状病毒肺炎感染与HIV检测中反复出现的假阳性效应:一例报告

COVID-19 infection and a repeated false positivity effect in HIV testing: A case report.

作者信息

Balasubramanian Anupama, Singh Devika, Lahey Timothy

机构信息

University of Vermont, Robert Larner College of Medicine, United States.

出版信息

IDCases. 2023 Oct 8;34:e01908. doi: 10.1016/j.idcr.2023.e01908. eCollection 2023.

DOI:10.1016/j.idcr.2023.e01908
PMID:37860150
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10582350/
Abstract

Several reports in the literature have described the association between SARS-CoV-2 infection and false positive HIV testing results. We present a case of a cisgender male who has sex with men with a false positive HIV test after fully recovering from COVID-19 14 days prior. Initial 4th generation HIV 1 and 2 antibody/antigen testing was positive twice, but confirmatory antibody testing was negative. HIV viral load was persistently undetectable. Most of the previously published case reports describe concurrent testing and positivity for HIV and COVID-19. Our report stands out due to the implication of a potentially prolonged association that could persist for several weeks.

摘要

文献中的几份报告描述了严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染与艾滋病毒检测结果呈假阳性之间的关联。我们报告了一例与男性发生性行为的顺性别男性病例,该患者在14天前从新冠肺炎中完全康复后,艾滋病毒检测结果呈假阳性。最初的第四代艾滋病毒1型和2型抗体/抗原检测两次均呈阳性,但确证性抗体检测为阴性。艾滋病毒病毒载量一直无法检测到。之前发表的大多数病例报告描述的是艾滋病毒和新冠肺炎同时检测且结果呈阳性的情况。我们的报告很突出,因为其中涉及一种可能持续数周的潜在长期关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bd/10582350/6e55f95de485/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bd/10582350/6e55f95de485/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99bd/10582350/6e55f95de485/gr1.jpg

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本文引用的文献

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Increase in False-Positive Fourth-Generation Human Immunodeficiency Virus Tests in Patients With Coronavirus Disease 2019.新冠肺炎患者第四代人类免疫缺陷病毒检测假阳性率增加。
Clin Infect Dis. 2023 Aug 22;77(4):615-619. doi: 10.1093/cid/ciad264.
2
False-Positive Human Immunodeficiency Virus Results in COVID-19 Patients.新冠病毒感染患者出现人类免疫缺陷病毒假阳性结果。
Cureus. 2023 Jan 23;15(1):e34096. doi: 10.7759/cureus.34096. eCollection 2023 Jan.
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Increased risk of false-positive HIV ELISA results after COVID-19.感染新冠病毒后 HIV ELISA 检测结果假阳性风险增加。
AIDS. 2023 May 1;37(6):947-950. doi: 10.1097/QAD.0000000000003507. Epub 2023 Feb 7.
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Machine-Learning-Assisted Analysis of TCR Profiling Data Unveils Cross-Reactivity between SARS-CoV-2 and a Wide Spectrum of Pathogens and Other Diseases.机器学习辅助的TCR谱分析数据揭示了新冠病毒与多种病原体及其他疾病之间的交叉反应性。
Biology (Basel). 2022 Oct 19;11(10):1531. doi: 10.3390/biology11101531.
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Long COVID and its Management.长新冠及其管理。
Int J Biol Sci. 2022 Jul 11;18(12):4768-4780. doi: 10.7150/ijbs.75056. eCollection 2022.
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False-Positive Human Immunodeficiency Virus Reactivity in COVID Patients: A Word of Caution.新冠患者中人类免疫缺陷病毒检测的假阳性反应:一则警示
J Glob Infect Dis. 2022 Feb 28;14(1):43-44. doi: 10.4103/jgid.jgid_226_21. eCollection 2022 Jan-Mar.
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