Zhu Hehao, Wei Yaping, He Qiangqiang, Song Yun, Liu Lishun, Sun Yong, Zhang Hao, Guo Huiyuan, Xu Xiping, Wang Binyan
School of Science, China Pharmaceutical University, Nanjing, China.
College of Public Health, Shanghai University of Medicine and Health Sciences, Shanghai, China.
Front Oncol. 2023 Oct 4;13:1223579. doi: 10.3389/fonc.2023.1223579. eCollection 2023.
Iron is an essential element for organismal health but excessive iron is potentially toxic. However, few observational studies link plasma iron (PI) concentrations and cancer risk, and the results are inconsistent.
This study aimed to explore the associations of PI concentrations with cancer risk in Chinese adults with hypertension.
We conducted a nested, case-control study, including 223 pairs of incident cancer cases and matched controls from the China Stroke Primary Prevention Trial. The median time between blood sample collection and subsequent cancer event occurrence was 2.13 years. The odds ratio (OR) and 95% confidence interval (CI) for the risk of cancer by PI were estimated from multivariable conditional logistic regression models.
There was a nonlinear association between PI concentrations and total cancer risk. When compared with participants in tertile 2 of PI, the ORs of total cancer were 2.17 (95%CI: 1.25-3.85) and 1.29 (95%CI: 0.77-2.19) in participants in PI tertiles 3 and 1, respectively. Furthermore, higher PI was associated with increased digestive system cancer risk (OR=3.25, 95%CI:1.29-8.90), while lower PI was associated with increased risk of non-digestive system cancer (OR=3.32, 95%CI: 1.39-8.71). In a sensitivity analysis, the increases in total cancer risk or digestive system cancer risk were still observed with higher PI after excluding cancer cases occurring within the first year.
Our results showed an increased risk of cancer related to higher PI or lower PI in Chinese adults with hypertension. Higher iron levels were linked to an increased risk of digestive system cancers, whereas lower iron levels were linked to an increased risk of non-digestive system cancers.
铁是机体健康的必需元素，但过量的铁可能具有毒性。然而，很少有观察性研究将血浆铁（PI）浓度与癌症风险联系起来，且结果并不一致。
本研究旨在探讨中国高血压成年人中PI浓度与癌症风险的关联。
我们进行了一项巢式病例对照研究，纳入了来自中国脑卒中一级预防试验的223对新发癌症病例及匹配的对照。血液样本采集与随后癌症事件发生之间的中位时间为2.13年。通过多变量条件逻辑回归模型估计PI与癌症风险的比值比（OR）及95%置信区间（CI）。
PI浓度与总体癌症风险之间存在非线性关联。与PI三分位数2中的参与者相比，PI三分位数3和1中的参与者总体癌症的OR分别为2.17（95%CI：1.25 - 3.85）和1.29（95%CI：0.77 - 2.19）。此外，较高的PI与消化系统癌症风险增加相关（OR = 3.25，95%CI：1.29 - 8.90），而较低的PI与非消化系统癌症风险增加相关（OR = 3.32，95%CI：1.39 - 8.71）。在敏感性分析中，排除第一年发生的癌症病例后，较高的PI仍与总体癌症风险或消化系统癌症风险增加相关。
我们的结果表明，中国高血压成年人中，较高或较低的PI与癌症风险增加相关。较高的铁水平与消化系统癌症风险增加相关，而较低的铁水平与非消化系统癌症风险增加相关。
