Chen Hua-Fei, Wu Li-Xin, Li Xiao-Feng, Zhu You-Cai, Wang Wen-Xian, Xu Chun-Wei, Xie Dong-Fang, Huang Jian-Hui, Du Kai-Qi
Department of Thoracic Disease Center, Zhejiang Rongjun Hospital, Jiaxing, 314000, Zhejiang Province, China.
Department of Chemotherapy, Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang Province, China.
Cell Mol Biol (Noisy-le-grand). 2018 Oct 30;64(13):33-37.
Many studies conducted on the relationship between serum iron levels and lung cancer risk had produced inconsistent results. We therefore conducted a meta-analysis to determine whether serum iron levels were lower in lung cancer patients compared to those in controls.A literature survey was conducted by searching the PubMed, WanFang, CNKI, and SinoMed databases for articles published as of Mar 1, 2018. Standard mean differences (SMD) with the corresponding 95% confidence intervals (CI) were executed by Stata 12.0 software. A total of 13 publications involving 1118 lung cancer patients and 832 controls were included in our study. The combined results showed that serum iron levels in lung cancer cases had no significantly lower when compared to those in controls [summary SMD = -0.125, 95%CI= -0.439, 0.189, Z = 0.78, p for Z test= 0.435], with high heterogeneity (I2= 89.9%, P< 0.001) found. In the stratified analysis by geographic locations, consistent results were found for serum iron levels between lung cancer patients and controls both in Asian populations [summary SMD = -0.113, 95%CI= -0.471, 0.245] and European populations [summary SMD = -0.215, 95%CI= -0.835, 0.404]. Publication bias was not found when evaluated by Begg's funnel plot and Egger's regression asymmetry test.In summary, the current study showed that serum iron levels had no significant association on lung cancer risk.
许多关于血清铁水平与肺癌风险之间关系的研究结果并不一致。因此，我们进行了一项荟萃分析，以确定肺癌患者的血清铁水平是否低于对照组。通过检索PubMed、万方、知网和中国生物医学文献数据库，对截至2018年3月1日发表的文章进行了文献调查。使用Stata 12.0软件计算标准平均差（SMD）及其相应的95%置信区间（CI）。我们的研究共纳入了13篇文献，涉及1118例肺癌患者和832例对照。合并结果显示，肺癌患者的血清铁水平与对照组相比无显著降低[汇总SMD = -0.125，95%CI = -0.439，0.189，Z = 0.78，Z检验p值 = 0.435]，且存在高度异质性（I2 = 89.9%，P < 0.001）。在按地理位置进行的分层分析中，亚洲人群[汇总SMD = -0.113，95%CI = -0.471，0.245]和欧洲人群[汇总SMD = -0.215，95%CI = -0.835，0.404]的肺癌患者与对照组之间血清铁水平的结果一致。通过Begg漏斗图和Egger回归不对称检验评估时未发现发表偏倚。总之，本研究表明血清铁水平与肺癌风险无显著关联。
