Buurma Niklaas J, Bagley Scott W
Physical Organic Chemistry Centre, School of Chemistry, Cardiff University Main Building, Park Place Cardiff CF10 3AT UK
Pfizer Medicine Design Eastern Point Road Groton CT 06340 USA
Chem Sci. 2023 Sep 27;14(40):10994-10996. doi: 10.1039/d3sc90145a. eCollection 2023 Oct 18.
Chemists know the value of looking at a reaction for clues about reaction progress and success, but what-it-looks-like has never been quantified. Reid and co-workers (C. Yan, M. Cowie, C. Howcutt, K. M. P. Wheelhouse, N. S. Hodnett, M. Kollie, M. Gildea, M. H. Goodfellow and M. Reid, , 2023, , 5323-5331, https://doi.org/10.1039/d2sc05702f) have developed an approach that uses camera footage of reactions to obtain quantitative descriptors of changes in reaction mixtures to support kinetic analysis.
化学家们知道观察反应以获取有关反应进程和成功线索的价值,但反应的外观从未被量化过。里德及其同事(C. 严、M. 考伊、C. 豪卡特、K. M. P. 惠尔豪斯、N. S. 霍德内特、M. 科利、M. 吉尔迪亚、M. H. 古德费洛和M. 里德,《化学科学》,2023年,第14卷,第5323 - 5331页,https://doi.org/10.1039/d2sc05702f)开发了一种方法,该方法利用反应的摄像 footage 来获得反应混合物变化的定量描述符,以支持动力学分析。