Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
Clin Exp Pharmacol Physiol. 2022 Aug;49(8):903-922. doi: 10.1111/1440-1681.13678. Epub 2022 Jun 22.
Bromocriptine is a sympatholytic dopamine D2 receptor agonist with remarkable bioactivities. It has been used clinically as a prescription drug for more than 30 years to treat hyperprolactinemia associated conditions, Parkinson's disease, acromegaly, prolactinomas and other pituitary hormone dependent adenomas and recently, diabetes mellitus as well as various other disorders. Long-term treatment with bromocriptine has minimal or no harmful effects on renal, hepatic, cardiac or hematologic functions. This review article was planned to study the hypothetical and proposed mechanism of action as well as provide a brief discussion about its safety issues and tolerability. Bromocriptine represents an attractive option with high efficacy and safety profile for hyperprolactinemia-associated conditions, acromegaly, parkinsonism, type 2 diabetes mellitus and various other diseases in a variety of dosage forms for best possible beneficial effects. It appeared to be an effective and safe addition to the pharmacopoeia of drugs for the treatment of a vast variety of diseases as monotherapy or in combination with other drugs.
溴隐亭是一种具有显著生物活性的交感神经抑制剂和多巴胺 D2 受体激动剂。它已在临床上作为处方药物使用超过 30 年，用于治疗与高催乳素血症相关的疾病、帕金森病、肢端肥大症、催乳素瘤和其他垂体激素依赖性腺瘤，以及最近的糖尿病和各种其他疾病。长期使用溴隐亭对肾脏、肝脏、心脏或血液功能几乎没有或没有有害影响。本文旨在研究其假设和提出的作用机制，并简要讨论其安全性和耐受性问题。溴隐亭对于与高催乳素血症相关的疾病、肢端肥大症、帕金森病、2 型糖尿病和各种其他疾病，以各种剂型提供了高效和安全的选择，具有很高的疗效和安全性，可获得最佳的有益效果。它似乎是治疗各种疾病的药物典中的有效且安全的附加药物，无论是单独使用还是与其他药物联合使用。
