Wei Lisi, Wang Xin, Wu Ling-Gang
National Institute of Neurological Disorders and Stroke , Bethesda, MD, USA.
J Cell Biol. 2023 Nov 6;222(11). doi: 10.1083/jcb.202310047. Epub 2023 Oct 20.
Exocytosis releases vesicular contents to mediate physiological functions. In this issue, Biton et al. (https://doi.org/10.1083/jcb.202302112) found four modes of releasing micron-sized exocrine vesicles and the underlying mechanisms involving actomyosin and BAR domain proteins. We highlight their discovery, compare it with much smaller/faster neuroendocrine vesicle fusion, and draw distinct and conserved principles regarding their membrane transformations, pore dynamics, and underlying mechanisms.
