Fujita Akiko, Ihara Kazushige, Kawai Hisashi, Obuchi Shuichi, Watanabe Yutaka, Hirano Hirohiko, Fujiwara Yoshinori, Takeda Yoichi, Tanaka Masashi, Kato Keiko
Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-Ku, Kyoto, 603-8555, Japan.
Department of Social Medicine, Graduate School of Medicine and School of Medicine, Hirosaki University, 5 Zaifu-Cho Hirosaki City, Aomori, 036-8562, Japan.
Discov Ment Health. 2022 Oct 27;2(1):20. doi: 10.1007/s44192-022-00023-0.
Mood and anxiety disorders are frequent in the elderly and increase the risk of frailty. This study aimed to identify novel biomarkers of major depressive disorder (MDD) and anxiety in the elderly. We examined 639 participants in the community-dwelling Otassha Study (518 individuals considered healthy control, 77 with depression, anxiety, etc.), mean age 75 years, 58.4% of female. After exclusion criteria, we analyzed VOCs from 18 individuals (9 healthy control, 9 of MDD/agoraphobia case). Urinary volatile and semi-volatile organic compounds (VOCs) were profiled using solid-phase microextraction and gas chromatography-mass spectrometry. Six urinary VOCs differed in the absolute area of the base peak between participants with MDD and/or agoraphobia and controls. High area under the receiver-operating characteristic curve (AUC) values were found for phenethyl isothiocyanate (AUC: 0.86, p = 0.009), hexanoic acid (AUC: 0.85, p = 0.012), texanol (AUC: 0.99, p = 0.0005), and texanol isomer (AUC: 0.89, p = 0.005). The combined indices of dimethyl sulfone, phenethyl isothiocyanate, and hexanoic acid, and texanol and texanol isomer showed AUCs of 0.91 (p = 0.003) and 0.99 (p = 0.0005) and correlated with the GRID-HAMD and the Kihon Checklist (CL score), respectively. These VOCs may be valuable biomarkers for evaluating MDD and/or agoraphobia in the elderly.
情绪和焦虑障碍在老年人中很常见，会增加虚弱的风险。本研究旨在确定老年人中重度抑郁症（MDD）和焦虑症的新型生物标志物。我们在社区居住的小田舍研究中检查了639名参与者（518名被视为健康对照，77名患有抑郁症、焦虑症等），平均年龄75岁，女性占58.4%。经过排除标准后，我们分析了18名个体（9名健康对照，9名MDD/广场恐惧症患者）的挥发性有机化合物（VOCs）。使用固相微萃取和气相色谱-质谱联用技术对尿液中的挥发性和半挥发性有机化合物（VOCs）进行了分析。MDD和/或广场恐惧症患者与对照组之间，有六种尿液VOCs的基峰绝对面积存在差异。异硫氰酸苯乙酯（曲线下面积[AUC]：0.86，p = 0.009）、己酸（AUC：0.85，p = 0.012）、异壬醇（AUC：0.99，p = 0.0005）和异壬醇异构体（AUC：0.89，p = 0.005）的AUC值较高。二甲基砜、异硫氰酸苯乙酯和己酸的联合指标，以及异壬醇和异壬醇异构体的联合指标，其AUC分别为0.91（p = 0.003）和0.99（p = 0.0005），且分别与汉密尔顿抑郁量表（GRID-HAMD）和简易精神状态检查表（CL评分）相关。这些VOCs可能是评估老年人MDD和/或广场恐惧症的有价值的生物标志物。
