Lueno Marian, Dobrowolny Henrik, Gescher Dorothee, Gbaoui Laila, Meyer-Lotz Gabriele, Hoeschen Christoph, Frodl Thomas
Department of Psychiatry and Psychotherapy, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Institute of Medical Engineering, Otto von Guericke University Magdeburg, Magdeburg, Germany.
Front Psychiatry. 2022 Jul 12;13:819607. doi: 10.3389/fpsyt.2022.819607. eCollection 2022.
Major depressive disorder (MDD) is a widespread common disorder. Up to now, there are no easy and frequent to use non-invasive biomarkers that could guide the diagnosis and treatment of MDD. The aim of this study was to investigate whether there are different mass concentrations of volatile organic compounds (VOCs) in the exhaled breath between patients with MDD and healthy controls. For this purpose, patients with MDD according to DSM-V and healthy subjects were investigated. VOCs contained in the breath were collected immediately after awakening, after 30 min, and after 60 min in a respective breath sample and measured using PRT-MS (proton-transfer-reaction mass spectrometry). Concentrations of masses m/z 88, 89, and 90 were significantly decreased in patients with MDD compared with healthy controls. Moreover, changes during the time in mass concentrations of m/z 93 and 69 significantly differed between groups. Differentiation between groups was possible with an AUCs of 0.80-0.94 in ROC analyses. In this first study, VOCs differed between patients and controls, and therefore, might be a promising tool for future studies. Altered masses are conceivable with energy metabolism in a variety of biochemical processes and involvement of the brain-gut-lung-microbiome axis.
重度抑郁症（MDD）是一种广泛存在的常见疾病。到目前为止，尚无简便且常用的非侵入性生物标志物可用于指导MDD的诊断和治疗。本研究的目的是调查MDD患者与健康对照者呼出气体中挥发性有机化合物（VOCs）的质量浓度是否存在差异。为此，对符合DSM-V标准的MDD患者和健康受试者进行了调查。在醒来后、30分钟后和60分钟后分别采集呼吸样本中的呼出气体所含的VOCs，并使用质子转移反应质谱（PRT-MS）进行测量。与健康对照者相比，MDD患者中质荷比为88、89和90的质量浓度显著降低。此外，两组之间质荷比为93和69的质量浓度随时间的变化存在显著差异。在ROC分析中，两组之间的区分可能性为AUC为0.80 - 0.94。在这项首次研究中，患者和对照者之间的VOCs存在差异，因此，VOCs可能是未来研究的一个有前景的工具。在各种生化过程中的能量代谢以及脑-肠-肺-微生物群轴的参与可能导致质量改变。
