Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, Shaanxi 710062, China.
Department of Food Science, The Pennsylvania State University, University Park, Pennsylvania 16802, United States.
J Agric Food Chem. 2023 Nov 1;71(43):16160-16173. doi: 10.1021/acs.jafc.3c06104. Epub 2023 Oct 20.
New evidence reveals that bol-miR159, an miRNA rich in fruits and vegetables, cross-kingdomly functions in mammalian bodies. However, whether the miRNA could regulate gut microbiota remains unclear. Here, the effect of miR159 on mouse intestinal microbes was comprehensively examined. The results showed that supplementation of miR159 to the chow diet significantly enhanced the diversity of mouse gut microbiota without causing pathological lesions or inflammatory responses on the intestines. At the phylum level, miR159 increased the abundance of Proteobacteria and decreased the Firmicute-to-Bacteroidetes (F/B) ratio. miR159 had prebiotic-like effects on mouse gut microbiota, as it promoted the growth of the bacteria that is beneficial for maintaining gut health. The miRNA can target bacteria genes and get into the bacteria cells. The data provide direct evidence on the crosstalk between plant miRNAs and intestinal microbes, highlighting the potential for miRNA-based strategies that modulate gut microbes to improve host health.
新证据表明，bol-miR159 是一种富含水果和蔬菜的 miRNA，可在哺乳动物体内进行跨物种功能。然而，miRNA 是否可以调节肠道微生物群尚不清楚。在这里，全面研究了 miR159 对小鼠肠道微生物的影响。结果表明，在饮食中补充 miR159 可显著增强小鼠肠道微生物群的多样性，而不会引起肠道的病理损伤或炎症反应。在门水平上，miR159 增加了变形菌门的丰度，降低了厚壁菌门与拟杆菌门的比值（F/B）。miR159 对小鼠肠道微生物群具有类似益生元的作用，因为它促进了对维持肠道健康有益的细菌的生长。miRNA 可以靶向细菌基因并进入细菌细胞。该数据为植物 miRNA 与肠道微生物之间的串扰提供了直接证据，突出了基于 miRNA 调节肠道微生物以改善宿主健康的策略的潜力。
