Gutsalenko O A, Bachinskiĭ P P
Probl Endokrinol (Mosk). 1986 Sep-Oct;32(5):22-8.
A total of 79 healthy persons (32 men and 47 women) and 109 patients with obvious diabetes mellitus (44 men and 65 women) were examined. The purpose of the investigation was to study the intensity of hydroyxproline excretion in the day-time and at night in the healthy persons and patients with diabetes mellitus with relation to sex, age, clinical type of a course of diabetes and the presence of vascular changes, duration and degree of disease activity and the state of compensation of diabetes mellitus. During a day the examinees collected two portions of urine: daily (6 a. m. to 10 p. m.) and night (10 p. m. to 6 a. m.) in which the concentration of hydroxyproline (in mumol/l) was determined and the intensity of hydroxyprolinuria was calculated (nmol/min), and these indices were determined for the entire daily cycle, too. The degree of expression of changes in hydroxyprolinuria in diabetes mellitus was shown to depend on sex and clinical type of disease: a more significant increase in hydroxyprolinuria was observed in the women, especially in insulin-dependent diabetes, whereas in the male patients such differences were less noticeable. The circadian rhythm was also more disturbed in the women. The determination of the intensity of hydroxyproline excretion can be used for the assessment of a degree of compensation of metabolic processes and the efficacy of therapeutic measures in diabetes mellitus.
共检查了79名健康人（32名男性和47名女性）和109名明显糖尿病患者（44名男性和65名女性）。调查目的是研究健康人和糖尿病患者白天和夜间羟脯氨酸排泄强度与性别、年龄、糖尿病病程临床类型、血管变化情况、疾病活动持续时间和程度以及糖尿病代偿状态的关系。在一天中，受检者收集两份尿液：日间（上午6点至晚上10点）和夜间（晚上10点至上午6点），测定其中羟脯氨酸浓度（以微摩尔/升计）并计算羟脯氨酸尿排泄强度（纳摩尔/分钟），这些指标也针对整个日周期进行测定。结果表明，糖尿病患者羟脯氨酸尿变化的表达程度取决于性别和疾病临床类型：女性尤其是胰岛素依赖型糖尿病患者中，羟脯氨酸尿排泄增加更为显著，而男性患者中这种差异不太明显。女性的昼夜节律也受到更大干扰。测定羟脯氨酸排泄强度可用于评估糖尿病代谢过程的代偿程度和治疗措施的疗效。
