Department of Population Health.
Department of Pediatrics, Dell Medical School.
J Infect Dis. 2024 Mar 14;229(3):719-727. doi: 10.1093/infdis/jiad459.
It is unclear whether there are racial/ethnic disparities in the risk of upper respiratory viral infection acquisition and/or lower respiratory manifestations.
We studied all children and children with asthma aged 6 to 17 years in the National Health and Nutrition Examination Survey (2007-2012) to evaluate (1) the association between race/ethnicity and upper respiratory infection (URI) and (2) whether race/ethnicity is a risk factor for URI-associated pulmonary eosinophilic inflammation or decreased lung function.
Children who identified as Black (adjusted odds ratio [aOR], 1.38; 95% CI, 1.10-1.75) and Mexican American (aOR, 1.50; 95% CI, 1.16-1.94) were more likely to report a URI than those who identified as White. Among those with asthma, Black children were more than twice as likely to report a URI than White children (aOR, 2.28; 95% CI, 1.31-3.95). Associations between URI and pulmonary eosinophilic inflammation or lung function did not differ by race/ethnicity.
Findings suggest that there may be racial and ethnic disparities in acquiring a URI but not in the severity of infection. Given that upper respiratory viral infection is tightly linked to asthma exacerbations in children, differences in the risk of infection among children with asthma may contribute to disparities in asthma exacerbations.
目前尚不清楚在上呼吸道病毒感染的发生风险和/或下呼吸道表现方面是否存在种族/民族差异。
我们研究了全国健康和营养检查调查（2007-2012 年）中的所有儿童和患有哮喘的儿童（6-17 岁），以评估（1）种族/民族与上呼吸道感染（URI）之间的关联，以及（2）种族/民族是否为 URI 相关的肺嗜酸性粒细胞炎症或肺功能下降的危险因素。
与白人相比，自认为是黑人（调整后的优势比 [aOR]，1.38；95%可信区间 [CI]，1.10-1.75）和墨西哥裔美国人（aOR，1.50；95%CI，1.16-1.94）的儿童更有可能报告 URI。在患有哮喘的儿童中，黑人儿童报告 URI 的可能性是白人儿童的两倍多（aOR，2.28；95%CI，1.31-3.95）。URI 与肺嗜酸性粒细胞炎症或肺功能之间的关联不因种族/民族而异。
研究结果表明，URI 的发生可能存在种族和民族差异，但感染的严重程度没有差异。鉴于上呼吸道病毒感染与儿童哮喘加重密切相关，哮喘儿童感染风险的差异可能导致哮喘加重的差异。
