Morato G S, Souza M L, Pires M L, Masur J
Pharmacol Biochem Behav. 1986 Oct;25(4):739-42. doi: 10.1016/0091-3057(86)90379-5.
The influence of pretreatment with 5.0 or 10.0 mg/kg of indomethacin, a prostaglandin synthetase inhibitor, on the alterations in body temperature produced by 3.0 and 4.0 g/kg of ethanol, was studied in food-deprived and free-feeding rats. A partial antagonism of ethanol's hypothermic effect resulted from indomethacin pretreatments and this effect was found to be ethanol dose-dependent. This result could account for the conflicting reports in the literature on the effectiveness of indomethacin in antagonizing ethanol-induced hypothermia. Indomethacin (5.0 mg/kg) also antagonized ethanol-induced hypoglycemia in 48 hr starved rats. The relationship between two effects of ethanol, hypothermia and hypoglycemia, is discussed.
在禁食和自由进食的大鼠中，研究了用5.0或10.0毫克/千克的吲哚美辛（一种前列腺素合成酶抑制剂）预处理对3.0和4.0克/千克乙醇引起的体温变化的影响。吲哚美辛预处理导致乙醇降温作用的部分拮抗，且该作用呈乙醇剂量依赖性。这一结果可以解释文献中关于吲哚美辛拮抗乙醇诱导的体温过低有效性的相互矛盾的报道。吲哚美辛（5.0毫克/千克）也拮抗了48小时饥饿大鼠中乙醇诱导的低血糖。文中讨论了乙醇的两种作用（体温过低和低血糖）之间的关系。
