Zimmerberg B, Riley E P, Glick S D
Pharmacol Biochem Behav. 1986 Nov;25(5):1021-5. doi: 10.1016/0091-3057(86)90080-8.
The effects of prenatal exposure to alcohol on behavioral correlates of catecholaminergic function were examined in three experiments. In each experiment, subjects had one of 3 prenatal treatment histories: prenatal alcohol-exposed (35% ethanol-derived-calories, 35% EDC), nutritional control (0% ethanol-derived calories, 0% EDC) or standard control (lab chow, LC). In the first experiment, juvenile (33 to 59 days of age) female rats were tested for 16 hours overnight in standard rotometers. Subjects in the 35% EDC group were more active compared to both control groups, who did not differ from each other. However, the degree of circling (rotation) was not altered by prenatal exposure to alcohol. Since there was a positive correlation between age and rotation in the LC group, but not in the other 2 groups, adult female rats were similarly tested overnight in the rotometer. Again, circling behavior was not differentially affected by prenatal exposure to alcohol. Total overnight activity was no longer significantly greater in the adult 35% EDC group, although their initial activity was higher than that of the LC control group. In the third experiment, subjects from Experiment 2 were administered d-amphetamine (1.25 mg/kg) and tested in the rotometer for 1 hour. Both rotation and activity were increased by d-amphetamine, but there was not a significant interaction with prenatal alcohol exposure. Since rotation is a reflection of the intrinsic asymmetry of the nigrostriatal system, these results suggest that prenatal exposure to alcohol does not alter the development of this asymmetry.
在三个实验中研究了产前暴露于酒精对儿茶酚胺能功能行为相关性的影响。在每个实验中，实验对象有三种产前治疗史之一：产前酒精暴露组（35%乙醇衍生热量，35% EDC）、营养对照组（0%乙醇衍生热量，0% EDC）或标准对照组（实验室饲料，LC）。在第一个实验中，幼年（33至59日龄）雌性大鼠在标准旋转计中进行了16小时的过夜测试。35% EDC组的实验对象比两个对照组更活跃，而两个对照组之间没有差异。然而，产前暴露于酒精并没有改变转圈（旋转）的程度。由于LC组中年龄与旋转之间存在正相关，而其他两组中不存在这种相关性，因此成年雌性大鼠也在旋转计中进行了类似的过夜测试。同样，产前暴露于酒精对转圈行为没有差异影响。成年35% EDC组的总过夜活动不再显著高于其他组，尽管其初始活动高于LC对照组。在第三个实验中，给来自实验2的实验对象注射d-苯丙胺（1.25 mg/kg），并在旋转计中测试1小时。d-苯丙胺增加了旋转和活动，但与产前酒精暴露没有显著的相互作用。由于旋转反映了黑质纹状体系统的内在不对称性，这些结果表明产前暴露于酒精不会改变这种不对称性的发育。
