Barron S, Riley E P
Alcohol Clin Exp Res. 1985 Jul-Aug;9(4):360-5. doi: 10.1111/j.1530-0277.1985.tb05560.x.
The effects of prenatal alcohol exposure on pup-induced maternal behaviors were examined in virgin rats whose mothers consumed liquid diets containing either 35 or 0% ethanol-derived-calories (EDC) on days 6-20 of gestation. A pair-feeding procedure was utilized to control for reduced caloric intake and, in addition, an ad libitum lab chow group was included to control for possible liquid diet effects. The results from experiments 1 and 2 revealed a sexually differential effect on this behavior in adult virgins exposed to alcohol in utero. Adult 35% EDC females showed a variety of deficits in maternal behaviors relative to controls; however, males with similar prenatal treatment appeared unaffected. In experiment 3, both 35% EDC male and female juveniles displayed altered maternal behaviors relative to controls. These results demonstrate yet another behavior sensitive to prenatal alcohol exposure. Prenatal hormonal alterations occurring as a consequence of maternal alcohol consumption may be a mechanism by which this long term behavioral effect is observed. This hypothesis and the importance of future research in this relatively new area of fetal alcohol studies are discussed.
在孕期第6至20天，给孕鼠喂食含有35%或0%乙醇热量（EDC）的流质饮食，然后对其雌性幼崽进行检查，观察产前酒精暴露对幼崽诱发的母性行为的影响。采用配对喂养程序来控制热量摄入的减少，此外，还纳入了自由采食实验室饲料的一组，以控制流质饮食可能产生的影响。实验1和实验2的结果表明，子宫内暴露于酒精的成年处女鼠在这种行为上存在性别差异。与对照组相比，成年摄入35% EDC的雌性在母性行为方面表现出各种缺陷；然而，接受类似产前处理的雄性似乎未受影响。在实验3中，摄入35% EDC的雄性和雌性幼崽相对于对照组均表现出母性行为改变。这些结果表明，又一种行为对产前酒精暴露敏感。孕期饮酒导致的产前激素变化可能是观察到这种长期行为影响的一种机制。本文讨论了这一假设以及在胎儿酒精研究这个相对较新的领域中未来研究的重要性。
