Molloy A G, Aronstam R S, Buccafusco J J
Pharmacol Biochem Behav. 1986 Nov;25(5):985-8. doi: 10.1016/0091-3057(86)90074-2.
The effects of clonidine, an indirectly-acting cholinergic antagonist, on 5 behaviors elicited by atropine (locomotion, rearing, sniffing, grooming and gnawing) were studied in rats. Clonidine did not alter the prevalence or magnitude of atropine-elicited locomotion and rearing. In contrast, clonidine suppressed the occurrence and degree of 3 stereotyped behaviors, namely, sniffing, grooming and gnawing. This selectivity of clonidine suggests differences in the neural pathways subserving the various stereotyped motor activities.
研究了间接作用的胆碱能拮抗剂可乐定对阿托品诱发的5种行为（运动、竖毛、嗅探、梳理和啃咬）在大鼠中的影响。可乐定并未改变阿托品诱发的运动和竖毛行为的发生率或程度。相比之下，可乐定抑制了3种刻板行为的发生和程度，即嗅探、梳理和啃咬。可乐定的这种选择性表明，参与各种刻板运动活动的神经通路存在差异。
