Ronald O. Perelman Department of Dermatology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.
Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Trends Cancer. 2024 Jan;10(1):28-37. doi: 10.1016/j.trecan.2023.09.006. Epub 2023 Oct 18.
Early in solid tumor development, antigens are presented in tumor-draining lymph nodes (tdLNs), a process that is necessary to set up immune surveillance. Recent evidence indicates that tdLNs fuel systemic tumor-specific T cell responses which may halt cancer progression and facilitate future responses to immunotherapy. These protective responses, however, are subject to progressive dysfunction exacerbated by lymph node (LN) metastasis. We discuss emerging preclinical and clinical literature indicating that the tdLN is a crucial reservoir for systemic immunity that can potentiate immune surveillance. We also discuss the impact of LN metastasis and argue that a better understanding of the relationship between LN metastasis and systemic immunity will be necessary to direct regional disease management in the era of immunotherapy.
在实体瘤发展的早期，抗原在肿瘤引流淋巴结（tdLNs）中呈递，这是建立免疫监视所必需的。最近的证据表明，tdLNs 为全身肿瘤特异性 T 细胞反应提供动力，这可能阻止癌症进展并促进未来对免疫疗法的反应。然而，这些保护反应受到淋巴结（LN）转移加剧的进行性功能障碍的影响。我们讨论了新兴的临床前和临床文献，表明 tdLN 是全身免疫的重要储库，可以增强免疫监视。我们还讨论了 LN 转移的影响，并认为为了在免疫治疗时代指导区域疾病管理，有必要更好地了解 LN 转移与全身免疫之间的关系。
