Meng Lingjun
Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Cell Death Discov. 2023 Oct 20;9(1):384. doi: 10.1038/s41420-023-01639-z.
The mechanism of nuclear size determination and alteration during normal lineage development and cancer pathologies which is not fully understood. As recently reported, chromatin modification can change nuclear morphology. Therefore, we screened a range of pharmacological chemical compounds that impact the activity of chromatin-modifying enzymes, in order to get a clue of the specific types of chromatin-modifying enzymes that remarkably effect nuclear size and shape. We found that interrupted activity of chromatin-modifying enzymes is associated with nuclear shape abnormalities. Furthermore, the activity of chromatin-modifying enzymes perturbs cell fate determination in cellular maintenance and lineage commitment. Our results indicated that chromatin-modifying enzyme regulates cell fate decision during lineage differentiation and is associate with nuclear size alteration.
在正常谱系发育和癌症病理过程中，细胞核大小的确定和改变机制尚未完全明了。正如最近报道的那样，染色质修饰可改变细胞核形态。因此，我们筛选了一系列影响染色质修饰酶活性的药理化合物，以期找到对细胞核大小和形状有显著影响的特定类型染色质修饰酶的线索。我们发现，染色质修饰酶活性的中断与细胞核形状异常有关。此外，染色质修饰酶的活性在细胞维持和谱系定向中扰乱细胞命运的决定。我们的结果表明，染色质修饰酶在谱系分化过程中调节细胞命运决定，并与细胞核大小改变相关。
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