School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 70 Nanyang Drive, Singapore, 637457, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore, 636921, Singapore.
Adv Mater. 2024 Jan;36(1):e2308924. doi: 10.1002/adma.202308924. Epub 2023 Oct 30.
Cancer immunotherapy has become a promising method for cancer treatment, bringing hope to advanced cancer patients. However, immune-related adverse events caused by immunotherapy also bring heavy burden to patients. Semiconducting polymer nanoparticles (SPNs) as an emerging nanomaterial with high biocompatibility, can eliminate tumors and induce tumor immunogenic cell death through different therapeutic modalities, including photothermal therapy, photodynamic therapy, and sonodynamic therapy. In addition, SPNs can work as a functional nanocarrier to synergize with a variety of immunomodulators to amplify anti-tumor immune responses. In this review, SPNs-based combination cancer immunotherapy is comprehensively summarized according to the SPNs' therapeutic modalities and the type of loaded immunomodulators. The in-depth understanding of existing SPNs-based therapeutic modalities will hopefully inspire the design of more novel nanomaterials with potent anti-tumor immune effects, and ultimately promote their clinical translation.
癌症免疫疗法已成为癌症治疗的一种有前途的方法，为晚期癌症患者带来了希望。然而，免疫疗法引起的免疫相关不良反应也给患者带来了沉重的负担。半导体聚合物纳米粒子（SPNs）作为一种新兴的纳米材料，具有很高的生物相容性，可通过不同的治疗方式消除肿瘤并诱导肿瘤免疫原性细胞死亡，包括光热疗法、光动力疗法和声动力疗法。此外，SPNs 还可以作为一种功能性纳米载体，与多种免疫调节剂协同作用，放大抗肿瘤免疫反应。在这篇综述中，根据 SPNs 的治疗方式和负载的免疫调节剂的类型，对基于 SPNs 的联合癌症免疫疗法进行了全面总结。深入了解现有的 SPNs 治疗方式有望激发设计更具强大抗肿瘤免疫效果的新型纳米材料，并最终促进其临床转化。
