Zhang Zhao, Lyu Jinxiao, Zhou Lu, Zhang Xuanjun
Faculty of Health Sciences, University of Macau, Macau SAR 999078, China.
ACS Appl Mater Interfaces. 2025 Jun 11;17(23):33465-33473. doi: 10.1021/acsami.5c03823. Epub 2025 Jun 2.
An interesting sunlight-driven photodynamic therapy (PDT) has been realized. In this study, we propose a strategy involving an intramolecular electron-donating ligand to develop a high-performance type-I photosensitizer. Specifically, an electron-rich core is flanked by two iridium atoms, facilitating electron transfer and promoting hydroxyl radical generation. The resulting Ir(III) photosensitizer, Q-T, boosts the rapid generation of reactive oxygen species (ROS) under low-intensity laser exposure. Moreover, the type-I ROS ideally suits hypoxic microenvironments, thus demonstrating remarkable PDT against various cell lines, under artificial and natural sunlight. In a skin squamous carcinoma (A431) organoid model, one cycle of treatment of dosing of Q-T followed by sunlight irradiation effectively induces cellular apoptosis and completely eradicates tumor organoids. This approach offers a promising avenue for the efficient PDT of skin cancer utilizing sunlight.
一种有趣的阳光驱动光动力疗法（PDT）已得以实现。在本研究中，我们提出了一种涉及分子内供电子配体的策略，以开发一种高性能的I型光敏剂。具体而言，一个富电子核心两侧有两个铱原子，这有利于电子转移并促进羟基自由基的产生。由此产生的铱（III）光敏剂Q-T在低强度激光照射下能促进活性氧（ROS）的快速生成。此外，I型ROS非常适合缺氧微环境，因此在人工阳光和自然阳光条件下，对各种细胞系都表现出显著的光动力疗法效果。在皮肤鳞状细胞癌（A431）类器官模型中，用Q-T给药后进行阳光照射的一个治疗周期能有效诱导细胞凋亡并完全根除肿瘤类器官。这种方法为利用阳光进行皮肤癌的高效光动力疗法提供了一条有前景的途径。
