Melanie E, Kittrell W, Satinoff E
Physiol Behav. 1986;38(1):99-104. doi: 10.1016/0031-9384(86)90138-1.
Seven male and seven female rat pups, all from separate litters of 10 pups each, had biotelemetry thermistors implanted into their peritoneal cavities when they were 10-15 days old. Body temperatures (Tb) were recorded by an Apple computer every 10 minutes until the rats were 60-75 days old so that the development of the circadian temperature rhythm (CTR) could be studied. The data were compared with eight parameters taken from adult CTRs. All rats were maintained on a 12 hr light/12 hr dark photoperiod. The results indicate that the CTR begins to develop after thermoregulatory mechanisms mature to produce an adult like daily range of TbS around day 24. From days 25 to 45, there was a steady increase in the percentage of TbS greater than the daily mean occurring in the dark. This process organized Tb into the characteristic sinusoidal waveform of the adult. Proper phasing of the trough and peak relative to the light/dark cycle took place between days 30-36. By day 42, 90% of TbS higher than the daily mean were occurring in the dark, while those lower than the mean were in the light. This is the typical adult pattern. The waveform's appearance continued to develop until day 50.
7只雄性和7只雌性幼鼠，均来自单独的一窝，每窝10只幼鼠，在10 - 15日龄时将生物遥测热敏电阻植入其腹腔。用苹果电脑每10分钟记录一次体温（Tb），直至大鼠60 - 75日龄，以便研究昼夜体温节律（CTR）的发育情况。将这些数据与从成年CTR获取的八个参数进行比较。所有大鼠均维持在12小时光照/12小时黑暗的光周期下。结果表明，在体温调节机制成熟以产生类似于成年动物的每日Tb范围后，CTR在第24天左右开始发育。从第25天到第45天，黑暗中Tb高于每日平均值的百分比稳步增加。这一过程将Tb组织成成年动物特有的正弦波形。波谷和波峰相对于明暗周期的正确相位在第30 - 36天之间形成。到第42天，90%高于每日平均值的Tb出现在黑暗中，而低于平均值的则出现在光照中。这是典型的成年模式。波形外观持续发育至第50天。
