Gordon C, Lavie P
Physiol Behav. 1986;38(3):307-13. doi: 10.1016/0031-9384(86)90099-5.
The effects of alpha and beta adrenoreceptors blockade and surgical kidney denervation on ultradian rhythmicity in urine excretion were investigated in four dogs. Pharmacological treatments and surgical denervation of the kidneys suppressed the ultradian rhythmicity in urine flow but did not completely eliminate the ultradian rhythms in urinary osmolality and in electrolyte concentrations. These findings suggest that the autonomic nervous system plays a major role in the regulation of the ultradian rhythms in water excretion in dogs. The partial persistence of ultradian rhythms in urine osmolality and electrolyte concentrations after autonomic denervation supports the assertion that the ultradian rhythms in solute concentrations are regulated by different mechanisms to those of water excretion, suggesting the possible involvement of a multioscillatory system.
在四只狗身上研究了α和β肾上腺素能受体阻断以及手术去肾神经支配对尿液排泄超日节律的影响。药理学治疗和肾脏手术去神经支配抑制了尿流的超日节律，但并未完全消除尿渗透压和电解质浓度的超日节律。这些发现表明，自主神经系统在调节狗的水排泄超日节律中起主要作用。自主神经去支配后尿渗透压和电解质浓度超日节律的部分持续存在支持了溶质浓度超日节律由与水排泄不同的机制调节这一观点，提示可能涉及多振荡系统。
