美国东南部综合癌症中心高级软组织肉瘤表现和结局的种族和民族差异。
Racial and ethnic variation in presentation and outcomes of high-grade soft tissue sarcoma at a Southeastern United States comprehensive cancer center.
机构信息
Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
Am J Surg. 2024 Jan;227:132-136. doi: 10.1016/j.amjsurg.2023.10.009. Epub 2023 Oct 5.
BACKGROUND
High-grade soft tissue sarcoma is rare and associated with poor prognosis. This study examines racial and ethnic variation in presentation and outcomes at a Southeastern US cancer center.
METHODS
Among an institutional cohort of patients seen between January 2016-December 2021, racial and ethnic differences were evaluated using chi-squared tests, Kaplan Meier curves, and Cox proportional hazards models.
RESULTS
There were 295 patients (71 % Non-Hispanic White, 24 % Black, 3 % Hispanic White, 2 % Other). Black representation was greater than national cohorts (24 % vs. 12 %). Histological subtype varied by race/ethnicity (p = 0.007). Adjusting for histology and stage, survival was worse for Black vs. White patients (HR 1.71, 95 % CI 1.07-2.76) and those with metastatic disease (5.47, 3.54-8.44). In non-metastatic patients, survival differences for Black vs. White patients were attenuated by receipt of multi-modal treatment (1.53, 0.82-2.88).
CONCLUSION
Observed racial disparities in survival of high-grade sarcoma may be addressed by early, multidisciplinary management.
背景
高级软组织肉瘤罕见，预后不良。本研究在美国东南部的一家癌症中心研究了种族和民族差异在表现和结果上的表现。
方法
在 2016 年 1 月至 2021 年 12 月期间观察到的机构队列患者中，使用卡方检验、Kaplan-Meier 曲线和 Cox 比例风险模型评估了种族和民族差异。
结果
共有 295 名患者（71%为非西班牙裔白人，24%为黑人，3%为西班牙裔白人，2%为其他）。黑人的代表性高于全国队列（24%对 12%）。种族/民族之间的组织学亚型不同（p=0.007）。调整组织学和分期后，与白人患者相比，黑人患者的生存情况更差（HR 1.71，95%CI 1.07-2.76），且患有转移性疾病的患者生存情况更差（HR 5.47，95%CI 3.54-8.44）。在非转移性患者中，黑人与白人患者之间的生存差异因接受多模式治疗而减弱（HR 1.53，95%CI 0.82-2.88）。
结论
高级肉瘤生存中观察到的种族差异可能通过早期的多学科管理来解决。
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