Patel Sunny J, Pappoppula Lakshmi, Guddati Achuta K
Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Division of Hematology/Oncology, Georgia Cancer Center, Augusta University, Augusta, GA, 30912, USA.
Int J Gen Med. 2021 Jul 24;14:3787-3791. doi: 10.2147/IJGM.S296309. eCollection 2021.
The clinical course of soft tissue sarcomas is often dependent on the grade of the tumor. The variability of incidence-based mortality in low-grade and high-grade soft tissue sarcomas (STS) with respect to gender and race over the past decade has not been well studied. This study analyzes the rates of incidence-based mortality from the years 2000 to 2016 amongst the grades, genders and racial groups of patients with STS.
The Surveillance, Epidemiology, and End Results (SEER) database was queried to conduct a nation-wide analysis for the years 2000 to 2016. Incidence-based mortality for all stages of low-grade and high-grade soft tissue sarcomas was queried and the results were grouped by race (Caucasian/White vs African American/Black) and gender. All stages and ages were included in the analysis and trend from 2000 to 2016 was analyzed.
The incidence-based mortality rates for Caucasians are similar to African Americans in both grades and genders. Rates were not analyzed for American Indian and Asian/Pacific Islanders due to small sample size. Mortality rates of high-grade soft tissue sarcomas were significantly higher compared to low-grade tumors. A higher rate of mortality is noted in Caucasian males compared to African Americans males despite past observations of higher incidence in African Americans. There was no significant change in the rate when trended over the past decade (2007 to 2016).
This study highlights the higher rate of incidence-based mortality in Caucasian males compared to African American males in the past 15 years despite a lower incidence reported in the 1995 to 2008 period. With no significant change in mortality rates/year noted during this time period, this study implies that soft tissue sarcomas in Caucasian males have worse outcomes. Further research is needed to understand the mechanism underlying this disparity.
软组织肉瘤的临床病程通常取决于肿瘤的分级。过去十年中，低级别和高级别软组织肉瘤（STS）基于发病率的死亡率在性别和种族方面的变异性尚未得到充分研究。本研究分析了2000年至2016年期间STS患者在不同分级、性别和种族组中的基于发病率的死亡率。
查询监测、流行病学和最终结果（SEER）数据库，对2000年至2016年进行全国范围分析。查询低级别和高级别软组织肉瘤所有阶段的基于发病率的死亡率，并按种族（白种人/白人对非裔美国人/黑人）和性别进行分组。分析纳入所有阶段和年龄，并分析2000年至2016年的趋势。
白种人的基于发病率的死亡率在分级和性别上与非裔美国人相似。由于样本量小，未对美国印第安人和亚洲/太平洋岛民的死亡率进行分析。高级别软组织肉瘤的死亡率明显高于低级别肿瘤。尽管过去观察到非裔美国人的发病率较高，但白种男性的死亡率高于非裔美国男性。在过去十年（2007年至2016年）趋势分析中，该比率没有显著变化。
本研究强调，尽管1995年至2008年期间报告白种男性的发病率较低，但在过去15年中，白种男性基于发病率的死亡率高于非裔美国男性。在此期间未观察到死亡率/年有显著变化，本研究表明白种男性的软组织肉瘤预后较差。需要进一步研究以了解这种差异背后的机制。
