Department of Pediatrics, University of California at San Francisco School of Medicine, 505 Parnassus Avenue, M646, San Francisco, CA 94143-0106, USA.
Cancer. 2010 Feb 15;116(4):983-8. doi: 10.1002/cncr.24865.
Ewing sarcoma (ES) was a malignant tumor of bone or soft tissue. One of the few risk factors for developing ES is race, with a higher incidence noted in populations of European rather than African or Asian ancestry. The goal of the current study was to evaluate racial and ethnic differences in presentation and overall survival (OS) among patients diagnosed with ES before age 40 years.
Data from the Surveillance, Epidemiology, and End Results database identified 1715 patients aged <40 years who were diagnosed with ES between 1973 and 2005. Racial and ethnic group differences were compared using chi-square tests. OS was estimated by Kaplan-Meier analysis and compared using log-rank tests and Cox models.
Black patients had significantly more soft-tissue tumors compared with white non-Hispanic patients (P <.0001). Asian and white Hispanic patients were found to have an intermediate frequency of soft-tissue tumors that also differed from white non-Hispanic patients (P <.0001). White Hispanic patients presented with a higher proportion of larger tumors compared with white non-Hispanic patients (P = .042). Black patients tended to be older than white non-Hispanic patients (P = .012). Sex, frequency of pelvic tumors, and metastatic status did not appear to differ by ethnicity or race. OS was found to differ according to race and ethnicity. Even after controlling for known confounders, OS was significantly worse for black, Asian, and white Hispanic patients compared with white non-Hispanic patients (P = .0031, P = .0182, and P = .0051, respectively).
Ethnic and racial differences in characteristics and outcomes of patients with ES do exist. Understanding the etiology of these differences will require further study.
尤因肉瘤（ES）是一种骨或软组织的恶性肿瘤。发生 ES 的少数危险因素之一是种族，欧洲裔人群的发病率高于非洲裔或亚洲裔人群。本研究的目的是评估种族和民族差异在 40 岁以下诊断为 ES 的患者的表现和总生存率（OS）。
从监测、流行病学和最终结果数据库中获得了 1973 年至 2005 年间诊断为 ES 的年龄<40 岁的 1715 名患者的数据。使用卡方检验比较种族和民族群体差异。使用 Kaplan-Meier 分析估计 OS，并使用对数秩检验和 Cox 模型进行比较。
与白人非西班牙裔患者相比，黑人患者的软组织肿瘤明显更多（P<.0001）。亚洲人和白人西班牙裔患者的软组织肿瘤发生率处于中间水平，也与白人非西班牙裔患者不同（P<.0001）。白人西班牙裔患者的肿瘤比例较大，与白人非西班牙裔患者相比（P=.042）。黑人患者的年龄大于白人非西班牙裔患者（P=.012）。性别、骨盆肿瘤的频率和转移状态似乎与种族或民族无关。OS 根据种族和民族而有所不同。即使在控制了已知的混杂因素后，黑人、亚洲人和白人西班牙裔患者的 OS 明显差于白人非西班牙裔患者（P=.0031、P=.0182 和 P=.0051）。
ES 患者的特征和结局存在种族和民族差异。了解这些差异的病因需要进一步研究。
