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干细胞科学中的知识阴影。

A Shadow of Knowledge in Stem Cell Science.

作者信息

Omid-Shafiee Sarina, Hassan Moustapha, Nussler Andreas K, Mustapha Najimi, Vosough Massoud

机构信息

Department of Regenerative Medicine, Cell science research center, Royan Institute for Stem Cell Biology, ACECR, Tehran, Iran.

Karolinska Institute.

出版信息

Cell J. 2023 Oct 1;25(10):738-740. doi: 10.22074/cellj.2023.2005680.1346.

DOI:10.22074/cellj.2023.2005680.1346
PMID:37865882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10591262/
Abstract

"Theory of Forms" implies that a genuine version of creatures exists beyond the shapes in this world. Stem cell
technology has adopted developmental cues to mimic real life. However, the functionality of the lab-made cells is far
from primary ones. Perhaps it is time to switch from analytical to systematic perspective in stem cell science. This
may be the way to define new horizons based on the systematic perspective and convergence of science in stem cell
biology, bridging the current gap between the shadows of real knowledge in current research and reality in future.

摘要

“形式理论”意味着生物的真实版本存在于这个世界的形状之外。干细胞技术采用发育线索来模拟现实生活。然而,实验室制造的细胞的功能与原始细胞相差甚远。也许是时候在干细胞科学中从分析视角转向系统视角了。这可能是基于系统视角和干细胞生物学中科学的融合来定义新视野的方法,弥合当前研究中真实知识的影子与未来现实之间的当前差距。

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Computational systems biology in disease modeling and control, review and perspectives.疾病建模与控制中的计算系统生物学:综述与展望。
NPJ Syst Biol Appl. 2022 Oct 3;8(1):37. doi: 10.1038/s41540-022-00247-4.
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Artificial Intelligence in Biological Sciences.生物科学中的人工智能
Life (Basel). 2022 Sep 14;12(9):1430. doi: 10.3390/life12091430.
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Human organs-on-chips for disease modelling, drug development and personalized medicine.用于疾病建模、药物开发和个性化医疗的人体器官芯片。
Nat Rev Genet. 2022 Aug;23(8):467-491. doi: 10.1038/s41576-022-00466-9. Epub 2022 Mar 25.
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Early human embryonic development: Blastocyst formation to gastrulation.早期人类胚胎发育:囊胚形成至原肠胚形成。
Dev Cell. 2022 Jan 24;57(2):152-165. doi: 10.1016/j.devcel.2021.12.022.
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Organoid and microfluidics-based platforms for drug screening in COVID-19.基于类器官和微流控的 COVID-19 药物筛选平台。
Drug Discov Today. 2022 Apr;27(4):1062-1076. doi: 10.1016/j.drudis.2021.12.014. Epub 2021 Dec 23.
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Organoids: a novel modality in disease modeling.类器官:疾病建模的一种新方法。
Biodes Manuf. 2021;4(4):689-716. doi: 10.1007/s42242-021-00150-7. Epub 2021 Aug 9.
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Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes.组织特异性微粒改善类器官微环境,以提高多能干细胞来源的肝细胞的成熟效率。
Cells. 2021 May 21;10(6):1274. doi: 10.3390/cells10061274.
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Evolution of organoid technology: Lessons learnt in Co-Culture systems from developmental biology.类器官技术的演进:从发育生物学中的共培养系统中吸取的经验教训。
Dev Biol. 2021 Jul;475:37-53. doi: 10.1016/j.ydbio.2021.03.001. Epub 2021 Mar 6.
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Toward Studying Cognition in a Dish.在培养皿中研究认知。
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Tissue Eng Part C Methods. 2021 Mar;27(3):183-199. doi: 10.1089/ten.TEC.2020.0300. Epub 2021 Feb 22.