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钝性腹部主动脉损伤的系统评价及死亡预测因素分析。

A systematic review of blunt abdominal aortic injury and analysis of predictors of death.

机构信息

Department of Vascular Surgery, Beijing Fengtai You'anmen Hospital, Beijing, China.

Department of Vascular Surgery, Peking Union Medical College Hospital, Beijing, China.

出版信息

Biomol Biomed. 2024 May 2;24(3):486-504. doi: 10.17305/bb.2023.9831.

Abstract

At present, research on blunt abdominal aortic injury (BAAI) is limited, with the majority being case reports. Consequently, there is a significant knowledge gap concerning this condition. To address this, we conducted a systematic review by extensively searching major databases. We included all literature that provided individual (non-identifiable) data on BAAI patients, irrespective of the study design. Furthermore, we undertook regression analyses to identify predictors of death after BAAI. The search yielded 2,099 results, leading to the inclusion of 102 case reports and one conference abstract. Using the Joanna Briggs Institute (JBI) checklist for assessment, all studies were deemed of medium to high quality. In total, 133 patients were included, with a median age of 34 years, and 73.7% being male. The predominant clinical manifestation was pain, reported in 65.6% of patients. The most frequently observed aortic lesion severity was grade A (intimal tear or intramural hematoma) at 46.9%, and the most common lesion location was zone III (infrarenal aorta) in 88.3% of cases.  The overall mortality after BAAI was 15.3%. Multivariate regression analyses revealed the following predictors of death after BAAI: lower limb ischemia (relative risk [RR] = 7.137, 95% confidence interval [CI] 1.154 - 44.161), cardiopulmonary arrest (RR = 10.250, 95% CI 1.452 - 72.344), and injuries to body parts other than the abdomen and lumbar spine (RR = 2.593, 95% CI 1.189 - 5.655). In conclusion, this review provides a detailed quantitative summary of BAAI's clinical manifestations, diagnosis, treatment, and prognosis, emphasizing its high mortality rate and identifying three critical variables as predictors of death.

摘要

目前,关于钝性腹主动脉损伤(BAAI)的研究有限,大多数为病例报告。因此,人们对这种疾病的认识存在很大的差距。为了解决这个问题,我们进行了系统的综述,广泛搜索了主要数据库。我们纳入了所有提供 BAAI 患者个体(不可识别)数据的文献,无论研究设计如何。此外,我们还进行了回归分析,以确定 BAAI 后死亡的预测因素。搜索结果产生了 2099 项结果,导致纳入了 102 例病例报告和一篇会议摘要。使用乔安娜·布里格斯研究所(JBI)评估清单,所有研究均被认为具有中等到高质量。总共纳入了 133 名患者,中位年龄为 34 岁,73.7%为男性。主要临床表现为疼痛,65.6%的患者有疼痛。观察到的最常见的主动脉损伤严重程度为 A 级(内膜撕裂或壁内血肿),占 46.9%,最常见的病变部位为 III 区(肾下主动脉),占 88.3%。BAAI 后的总体死亡率为 15.3%。多变量回归分析显示,BAAI 后死亡的预测因素包括下肢缺血(相对风险[RR] = 7.137,95%置信区间[CI] 1.154-44.161)、心肺骤停(RR = 10.250,95%CI 1.452-72.344)和腹部及腰椎以外的身体其他部位受伤(RR = 2.593,95%CI 1.189-5.655)。总之,本综述详细定量总结了 BAAI 的临床表现、诊断、治疗和预后,强调其高死亡率,并确定了三个关键变量作为死亡的预测因素。

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