Martignoni E, Facchinetti F, Manzoni G C, Petraglia F, Nappi G, Genazzani A R
Psychiatry Res. 1986 Sep;19(1):51-7. doi: 10.1016/0165-1781(86)90092-2.
The dexamethasone suppression test (DST) was administered in 48 daily chronic headache (DCH) sufferers, 37 of whom also suffered from mild to severe depression. In 14 of 48 subjects (29.2%), cortisol values at 1600h were greater than 50 ng/ml, despite normal suppression at 0800h. The escapers showed basal cortisol values and (Depression scale) scores on the Minnesota Multiphasic Personality Inventory higher than suppressors. Thus, a group of DCH sufferers appeared to share a biochemical defect often seen in endogenous depression. The escape from dexamethasone suppression could be a psychobiological indicator of vulnerability to develop depressive disorder and/or chronic pain complaints.
对48名每日患有慢性头痛（DCH）的患者进行了地塞米松抑制试验（DST），其中37人还患有轻至重度抑郁症。在48名受试者中的14人（29.2%）中，尽管08:00时抑制正常，但16:00时的皮质醇值大于50 ng/ml。逃脱抑制者的基础皮质醇值和明尼苏达多相人格调查表上的（抑郁量表）得分高于抑制者。因此，一组DCH患者似乎存在一种在内源性抑郁症中常见的生化缺陷。地塞米松抑制的逃脱可能是易患抑郁症和/或慢性疼痛主诉的心理生物学指标。
