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受裂变中子和伽马射线照射的小鼠寿命缩短。VI. 对白足鼠(白足鼠属)的研究。

Life shortening in mice exposed to fission neutrons and gamma rays. VI. Studies with the white-footed mouse, Peromyscus leucopus.

作者信息

Thomson J F, Williamson F S, Grahn D

出版信息

Radiat Res. 1986 Nov;108(2):176-88.

PMID:3786676
Abstract

Some of the studies on late effects of neutron and gamma radiation previously carried out with the C57BL6 X BALB/c F1 hybrids of Mus musculus have been repeated with the white-footed mouse, Peromyscus leucopus, a cricetid rodent of a different subfamily, with differing physiological characteristics and a different spectrum of pathologies. Among the more important findings were the following: For both species, the life shortening per rad at low doses of either radiation was the same percentage of the life span. The limiting values of the relative biological effectiveness for life shortening from all causes of death were about the same for the two species, ranging from 8 to 16, depending on the method of calculation. Fractionated neutron exposures failed to produce significant life shortening in Peromyscus over that observed at single doses. Tumor-related deaths accounted for at least 70 to 75% of the radiation-specific excess mortality in Peromyscus.

摘要

先前使用小家鼠的C57BL6 X BALB/c F1杂种对中子和γ辐射的晚期效应进行的一些研究,已对白足鼠(白足鼠属,属于不同亚科的仓鼠科啮齿动物,具有不同的生理特征和不同的病理谱)重复进行。其中一些更重要的发现如下:对于这两个物种,低剂量辐射下每拉德的寿命缩短占寿命的百分比相同。两种物种因各种死因导致寿命缩短的相对生物效应的极限值大致相同,根据计算方法的不同,范围在8至16之间。分次中子照射对白足鼠的寿命缩短作用并不比单次照射时显著。在白足鼠中,与肿瘤相关的死亡至少占辐射特异性额外死亡率的70%至75%。

相似文献

1
Life shortening in mice exposed to fission neutrons and gamma rays. VI. Studies with the white-footed mouse, Peromyscus leucopus.受裂变中子和伽马射线照射的小鼠寿命缩短。VI. 对白足鼠(白足鼠属)的研究。
Radiat Res. 1986 Nov;108(2):176-88.
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Life shortening in mice exposed to fission neutrons and gamma rays. V. Further studies with single low doses.受裂变中子和γ射线照射的小鼠的寿命缩短。V. 单次低剂量的进一步研究。
Radiat Res. 1985 Dec;104(3):420-8.
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Life shortening in mice exposed to fission neutrons and gamma rays. VIII. Exposures to continuous gamma radiation.受裂变中子和γ射线照射的小鼠寿命缩短。VIII. 连续γ辐射照射
Radiat Res. 1989 Apr;118(1):151-60.
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Limiting values for the RBE of fission neutrons at low doses for life shortening in mice.低剂量裂变中子对小鼠寿命缩短的相对生物效应(RBE)的限值。
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Life shortening in mice exposed to fission neutrons and gamma rays. IV. Further studies with fractionated neutron exposures.受裂变中子和γ射线照射的小鼠寿命缩短。IV. 分次中子照射的进一步研究。
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Life-shortening and disease incidence in C57Bl mice after single and fractionated gamma and high-energy neutron exposure.单次及分次γ射线和高能中子照射后C57Bl小鼠的寿命缩短及疾病发生率
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Analysis of survival and cause of death statistics for mice under single and duration-of-life gamma irradiation.单剂量及终身剂量γ射线照射下小鼠的生存及死亡原因统计分析
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Life shortening in mice exposed to fission neutrons and gamma rays. VII. Effects of 60 once-weekly exposures.暴露于裂变中子和γ射线的小鼠寿命缩短。VII. 每周一次,共60次照射的影响。
Radiat Res. 1988 Aug;115(2):347-60.
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Dose-response modeling of life shortening in a retrospective analysis of the combined data from the JANUS program at Argonne National Laboratory.在对阿贡国家实验室JANUS项目的合并数据进行回顾性分析时,对寿命缩短进行剂量反应建模。
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Life-shortening and disease incidence in mice after exposure to gamma rays or high-energy neutrons.暴露于伽马射线或高能中子后小鼠的寿命缩短及疾病发生率
Radiat Res. 1991 Oct;128(1 Suppl):S117-23.

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