贫血、补铁与大脑
Anemia, Iron Supplementation, and the Brain.
机构信息
Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue, SAO-401, Minneapolis, MN 55454, USA.
Division of Neonatology, Department of Pediatrics, University of Minnesota Medical School, Academic Office Building, 2450 Riverside Avenue, SAO-401, Minneapolis, MN 55454, USA.
出版信息
Clin Perinatol. 2023 Dec;50(4):853-868. doi: 10.1016/j.clp.2023.07.009. Epub 2023 Aug 31.
Abstract
The developing brain is particularly vulnerable to extrinsic environmental events such as anemia and iron deficiency during periods of rapid development. Studies of infants with postnatal iron deficiency and iron deficiency anemia clearly demonstrated negative effects on short-term and long-term brain development and function. Randomized interventional trials studied erythropoiesis-stimulating agents and hemoglobin-based red blood cell transfusion thresholds to determine how they affect preterm infant neurodevelopment. Studies of red blood cell transfusion components are limited in preterm neonates. A biomarker strategy measuring brain iron status and health in the preanemic period is desirable to evaluate treatment options and brain response.
摘要
发育中的大脑对外界环境事件特别敏感，例如在快速发育期间出现的贫血和铁缺乏。对出生后缺铁和缺铁性贫血婴儿的研究清楚地表明，这对短期和长期大脑发育和功能有负面影响。随机干预试验研究了促红细胞生成素刺激剂和基于血红蛋白的红细胞输血阈值，以确定它们如何影响早产儿的神经发育。关于早产儿红细胞输血成分的研究有限。在早产儿中，理想的方法是采用一种生物标志物策略来测量脑铁状态和健康状况，以评估治疗选择和大脑反应。
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