Department of Urology, Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Department of Vascular Surgery, Foundation IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milano, Italy.
Nutrients. 2022 Nov 1;14(21):4585. doi: 10.3390/nu14214585.
Lifestyle and environmental factors can negatively impact fertility by means of oxidative stress. In this context, antioxidant supplementation therapy has gained much interest in recent years, and different molecules, alone or in combination, have been studied.
The purpose of the present review is to investigate the evidence regarding the efficacy of coenzyme Q10 (CoQ10) and melatonin on male infertility.
A literature search using PUBMED database from 2000 to October 2022 was performed to explore the role of CoQ10 and melatonin on male reproductive function.
The analysis involved a narrative synthesis. CoQ10, alone or in combination, appears to reduce testicular oxidative stress and sperm DNA fragmentation and to improve sperm parameters; particularly sperm motility. Moreover, CoQ10 treatment is associated with higher pregnancy rates, both naturally and through assisted reproductive technology (ART). Larger studies are needed to precisely determine its clinical efficacy. Melatonin is a known antioxidant and preclinical studies have shown its ability to modulate reproductive function through hormonal and immune system regulation and sperm cell proliferation. Regardless, clinical studies are necessary to assess its potential in male infertility.
生活方式和环境因素可能通过氧化应激对生育能力产生负面影响。在这种情况下，抗氧化补充剂治疗近年来引起了广泛关注，并且已经研究了不同的分子，单独或联合使用。
本综述的目的是调查关于辅酶 Q10（CoQ10）和褪黑素对男性不育症疗效的证据。
使用 PUBMED 数据库从 2000 年到 2022 年 10 月进行文献检索，以探讨 CoQ10 和褪黑素对男性生殖功能的作用。
分析涉及叙述性综合。CoQ10 单独或联合使用似乎可以降低睾丸氧化应激和精子 DNA 碎片化，改善精子参数；特别是精子运动能力。此外，CoQ10 治疗与更高的妊娠率相关，无论是自然妊娠还是通过辅助生殖技术（ART）。需要更大规模的研究来准确确定其临床疗效。褪黑素是一种已知的抗氧化剂，临床前研究表明它通过调节激素和免疫系统以及精子细胞增殖来调节生殖功能。然而，仍需要临床研究来评估其在男性不育症中的潜力。
