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由[具体菌种1]和[具体菌种2]引起的侵袭性肺部合并感染，在一名接受第二次异基因造血干细胞移植的患者中并发[某种疾病]再激活——病例报告

Invasive pulmonary co-infection caused by sp. and , complicated by reactivation in a patient following second allogeneic hematopoietic stem cell transplantation - Case report.

作者信息

Niyazi Denis, Micheva Ilina, Petrov Yavor, Stoev Lyuben, Dimitrova Stela, Stoeva Temenuga

机构信息

Laboratory of Microbiology, University Hospital "St. Marina" - Varna, 9010, Varna, Bulgaria.

Medical University - Varna, 9002, Varna, Bulgaria.

出版信息

Med Mycol Case Rep. 2023 Oct 11;42:100613. doi: 10.1016/j.mmcr.2023.100613. eCollection 2023 Dec.

DOI:10.1016/j.mmcr.2023.100613
PMID:37867574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10587748/
Abstract

Invasive fungal infections are common complication in hematopoietic stem cell transplant recipients, often leading to high morbidity and mortality rates. Furthermore, when invasive fungal co-infections are diagnosed the prognosis is rarely favorable. Here, we present a rare case of a 47-year-old HIV-negative male with invasive pulmonary co-infection caused by sp. and , complicated by reactivation following second allogeneic hematopoietic stem cell transplantation with a fatal outcome. 2012 Elsevier Ltd. All rights reserved.

摘要

侵袭性真菌感染是造血干细胞移植受者常见的并发症，常导致高发病率和死亡率。此外，当诊断出侵袭性真菌合并感染时，预后很少良好。在此，我们报告一例罕见病例，一名47岁的HIV阴性男性，患有由sp.和引起的侵袭性肺部合并感染，并在第二次异基因造血干细胞移植后因再激活而复杂化，最终导致死亡。2012爱思唯尔有限公司。保留所有权利。 （注：原文中部分菌种名称未完整给出，翻译可能存在一定局限性）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/43fb4769c8e5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/e3cfce5d03c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/af26e50720c7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/d66f604d535a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/43fb4769c8e5/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/e3cfce5d03c4/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/af26e50720c7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/d66f604d535a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d53/10587748/43fb4769c8e5/gr4.jpg

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本文引用的文献

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A Systematic Review on Pulmonary Complications Secondary to Hematopoietic Stem Cell Transplantation.造血干细胞移植继发肺部并发症的系统评价
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造血干细胞移植患者真菌性肺炎的影像学特征
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Pneumocystis jirovecii: a review with a focus on prevention and treatment.卡氏肺孢子虫：预防与治疗为重点的综述
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Clinical evaluation of an in-house panfungal real-time PCR assay for the detection of fungal pathogens.临床评估一种内部真菌实时 PCR 检测方法对真菌病原体的检测。
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