• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

患有精神分裂症的巴塔克人中白细胞介素-10（-1082 G/A）基因多态性

IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia.

作者信息

Mardhiyah Sarah A, Effendy Elmeida, Nasution Nazli M

机构信息

Psychiatry Residency Program, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.

出版信息

J Taibah Univ Med Sci. 2023 Sep 11;19(1):64-69. doi: 10.1016/j.jtumed.2023.08.011. eCollection 2024 Feb.

DOI:10.1016/j.jtumed.2023.08.011
PMID:37868103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10589880/
Abstract

OBJECTIVES

Three biallelic polymorphisms at the promoter region of the interleukin-10 (IL-10) gene have been associated with susceptibility to schizophrenia. The aim of this case-control study was to investigate the association between IL-10 (-1082) G/A gene polymorphisms and schizophrenia among Bataknese, a native tribe inhabiting the North Sumatera province in Indonesia.

METHODS

A total of 194 unrelated participants (n = 97 for each case and control groups) participated in this study. Polymerase chain reaction restriction fragment length polymorphism molecular genotyping was conducted to assess the genotype and allele distribution of IL-10 (-1082 G/A).

RESULTS

Allele variations indicated that the dominant allele in the Batak tribe was allele A, whereas homozygous GG genotypes were not found in either group. The A allele and AA genotype were found to be risk factors for developing schizophrenia (OR = 2.26, 95% CI = 1.1825-4.3559 and OR = 2.56, 95% CI = 1.280-5.152, respectively).

CONCLUSION

Only the A allele and AA genotype of the IL-10 gene polymorphism at -1082 G/A contribute to schizophrenia susceptibility in Bataknese.

摘要

目的

白细胞介素-10（IL-10）基因启动子区域的三个双等位基因多态性与精神分裂症易感性相关。本病例对照研究的目的是调查居住在印度尼西亚北苏门答腊省的原住民巴塔克族中IL-10（-1082）G/A基因多态性与精神分裂症之间的关联。

方法

共有194名无亲属关系的参与者（病例组和对照组各97名）参与了本研究。采用聚合酶链反应-限制性片段长度多态性分子基因分型方法评估IL-10（-1082 G/A）的基因型和等位基因分布。

结果

等位基因变异表明，巴塔克部落的优势等位基因为A等位基因，而两组均未发现纯合GG基因型。发现A等位基因和AA基因型是患精神分裂症的危险因素（OR分别为2.26，95%CI为1.1825 - 4.3559；OR为2.56，95%CI为1.280 - 5.152）。

结论

在巴塔克族中，只有IL-10基因多态性-1082 G/A处的A等位基因和AA基因型与精神分裂症易感性有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4458/10589880/798a744fc2d7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4458/10589880/798a744fc2d7/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4458/10589880/798a744fc2d7/gr1.jpg

相似文献

1
IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia.患有精神分裂症的巴塔克人中白细胞介素-10（-1082 G/A）基因多态性
J Taibah Univ Med Sci. 2023 Sep 11;19(1):64-69. doi: 10.1016/j.jtumed.2023.08.011. eCollection 2024 Feb.
2
The Effect of Interleukin-2 -330 T/G Polymorphism in People with Schizophrenia Among The Batak and Javanese Ethnic Groups.白细胞介素-2-330T/G 多态性对巴塔克族和爪哇族精神分裂症患者的影响。
Med Arch. 2023;77(5):363-369. doi: 10.5455/medarh.2023.77.363-369.
3
Polymorphisms in proinflammatory cytokines genes and susceptibility to Multiple Sclerosis.促炎细胞因子基因多态性与多发性硬化症易感性
Mult Scler Relat Disord. 2021 Jan;47:102654. doi: 10.1016/j.msard.2020.102654. Epub 2020 Nov 28.
4
Interleukin-10 -1082 G/A gene polymorphisms in Egyptian children with CAP: A case-control study.埃及社区获得性肺炎儿童白细胞介素-10 -1082 G/A基因多态性：一项病例对照研究。
Medicine (Baltimore). 2016 Jun;95(26):e4013. doi: 10.1097/MD.0000000000004013.
5
Interleukin-1β and interleukin-1receptor antagonist polymorphisms in Egyptian children with febrile seizures: A case-control study.埃及热性惊厥儿童白细胞介素-1β和白细胞介素-1受体拮抗剂基因多态性：一项病例对照研究。
Medicine (Baltimore). 2017 Mar;96(11):e6370. doi: 10.1097/MD.0000000000006370.
6
Association of IL-10 gene polymorphisms and susceptibility to Juvenile Idiopathic Arthritis in Egyptian children and adolescents: a case-control study.白细胞介素-10基因多态性与埃及儿童及青少年特发性关节炎易感性的关联：一项病例对照研究
Ital J Pediatr. 2017 Jan 17;43(1):9. doi: 10.1186/s13052-017-0328-1.
7
Interleukin-10 gene promoter polymorphism in patients with schizophrenia in a region of East Turkey.东土耳其地区精神分裂症患者白细胞介素-10 基因启动子多态性。
World J Biol Psychiatry. 2009;10(4 Pt 2):461-8. doi: 10.1080/15622970802626580.
8
Interleukin-6 gene polymorphisms in Egyptian children with febrile seizures: a case-control study.埃及热性惊厥儿童白细胞介素-6基因多态性：一项病例对照研究。
Ital J Pediatr. 2016 Mar 9;42:31. doi: 10.1186/s13052-016-0244-9.
9
Association of IL-2 polymorphisms and IL-2 serum levels with susceptibility to HBV-related hepatocellular carcinoma in a Chinese Zhuang population.白细胞介素-2基因多态性及血清白细胞介素-2水平与中国壮族人群乙型肝炎病毒相关肝细胞癌易感性的关联
Infect Genet Evol. 2014 Oct;27:375-81. doi: 10.1016/j.meegid.2014.08.021. Epub 2014 Aug 27.
10
Association of cytokine gene polymorphisms with susceptibility to cutaneous leishmaniasis in a Turkish population.细胞因子基因多态性与土耳其人群皮肤利什曼病易感性的关联。
Parasite Immunol. 2020 Nov;42(11):e12775. doi: 10.1111/pim.12775. Epub 2020 Jul 30.

本文引用的文献

1
Learning mitigates genetic drift.学习可减轻基因漂变。
Sci Rep. 2022 Nov 27;12(1):20403. doi: 10.1038/s41598-022-24748-8.
2
The Role of Cytokines in the Pathogenesis of Schizophrenia.细胞因子在精神分裂症发病机制中的作用
J Clin Med. 2021 Aug 27;10(17):3849. doi: 10.3390/jcm10173849.
3
Lifetime Prevalence and Correlates of Schizophrenia and Other Psychotic Disorders in Singapore.新加坡精神分裂症及其他精神障碍的终生患病率及其相关因素
Front Psychiatry. 2021 Mar 11;12:650674. doi: 10.3389/fpsyt.2021.650674. eCollection 2021.
4
Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity.精神分裂症中的认知障碍：与额颞叶区域皮质厚度的关系，以及与症状严重程度的可分离性。
NPJ Schizophr. 2021 Mar 18;7(1):20. doi: 10.1038/s41537-021-00149-0.
5
Gender difference in the association between education and schizophrenia in Chinese adults.中国成年人中教育与精神分裂症之间关联的性别差异。
BMC Psychiatry. 2020 Jun 12;20(1):296. doi: 10.1186/s12888-020-02700-2.
6
Epidemiology of schizophrenia and its management over 8-years period using real-world data in Spain.精神分裂症的流行病学及其在西班牙使用真实世界数据进行的 8 年管理。
BMC Psychiatry. 2020 Apr 5;20(1):149. doi: 10.1186/s12888-020-02538-8.
7
Alterations of plasma cytokine biomarkers for identifying age at onset of schizophrenia with neurological soft signs.伴有神经软体征的精神分裂症发病年龄的血浆细胞因子生物标志物改变。
Int J Med Sci. 2020 Jan 14;17(2):255-262. doi: 10.7150/ijms.38891. eCollection 2020.
8
Population structure in genetic studies: Confounding factors and mixed models.遗传研究中的群体结构：混杂因素与混合模型。
PLoS Genet. 2018 Dec 27;14(12):e1007309. doi: 10.1371/journal.pgen.1007309. eCollection 2018 Dec.
9
Cytokine alterations in first-episode schizophrenia and bipolar disorder: relationships to brain structure and symptoms.首发精神分裂症和双相情感障碍的细胞因子改变：与脑结构和症状的关系。
J Neuroinflammation. 2018 May 26;15(1):165. doi: 10.1186/s12974-018-1197-2.
10
Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016.全球精神分裂症的流行病学和负担：来自 2016 年全球疾病负担研究的结果。
Schizophr Bull. 2018 Oct 17;44(6):1195-1203. doi: 10.1093/schbul/sby058.