Rahali Fatima Zahra, Bounani Fatima, Babokh Fatima, El Hakkouni Awatif
Department of Clinical Laboratory, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Marrakesh, MAR.
Department of Biology/Department of Parasitology and Mycology, Faculty of Medicine and Pharmacy, Mohammed VI University Hospital, Cadi Ayyad University, Marrakesh, MAR.
Cureus. 2023 Sep 19;15(9):e45568. doi: 10.7759/cureus.45568. eCollection 2023 Sep.
() is an opportunistic arthroconidial yeast-like fungus causing invasive infections in immunocompromised patients, mainly those with hematological malignancies and severe neutropenia. However, infections due to are extremely rare in immunocompetent and non-neutropenic patients. spp. are microscopically characterized by arthroconidia with hyaline-septated hyphae. is known to be intrinsically resistant to echinocandins and highly resistant to fluconazole. It is suggested to use amphotericin B or voriconazole (in monotherapy or in combination) as the gold standard treatment for systemic infections. We report a rare case of peritonitis with fatal outcome in a non-neutropenic patient without underlying malignancies. This case report highlights the value of direct microscopic examination and stained smears in a prompt preliminary diagnosis of invasive fungal infections. We also aim to emphasize the importance of early initiation of appropriate antifungal treatment in patients with systemic infections, thus improving their therapeutic outcome.
（）是一种机会性节孢子酵母菌样真菌，可在免疫功能低下的患者中引起侵袭性感染，主要是那些患有血液系统恶性肿瘤和严重中性粒细胞减少症的患者。然而，在免疫功能正常和非中性粒细胞减少的患者中，由（）引起的感染极为罕见。（）属在显微镜下的特征是具有透明分隔菌丝的节孢子。已知（）对棘白菌素具有固有抗性，对氟康唑高度耐药。建议使用两性霉素B或伏立康唑（单药治疗或联合治疗）作为全身感染的金标准治疗方法。我们报告了一例非中性粒细胞减少且无潜在恶性肿瘤的患者发生（）腹膜炎并导致死亡的罕见病例。本病例报告强调了直接显微镜检查和染色涂片在（）侵袭性真菌感染快速初步诊断中的价值。我们还旨在强调在（）全身感染患者中早期开始适当抗真菌治疗的重要性，从而改善其治疗结果。
