Bariş Ayşe, Gencer Haşim, Dalgiç Nazan, Şik Güntülü, Özakkaş Fatma, Aktaş Elif
From the University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Clinical Microbiology Laboratory, Istanbul, Turkey.
Pediatr Infect Dis J. 2017 Dec;36(12):e351-e353. doi: 10.1097/INF.0000000000001720.
Magnusiomyces capitatus is an emerging opportunistic fungal pathogen particularly in immunocompromised patients. We report a case of a M. capitatus peritonitis in child with acute lymphocytic leukemia as a breakthrough infection during caspofungin therapy. The possibility of breakthrough infections caused by M. capitatus must be taken into consideration, particularly in immunosupressed patients being treated for systemic fungal infections by caspofungin. Although there are no defined breakpoints for susceptibility testing of M.capitatus, minimal inhibitory concentration results can be helpful for therapy. Antifungal treatment with amphotericin B lipid complex plus flucytosine can be effective against infections caused by M. capitatus.
头状马格努斯酵母是一种新出现的机会性真菌病原体，尤其在免疫功能低下的患者中。我们报告了一例患有急性淋巴细胞白血病的儿童发生头状马格努斯酵母腹膜炎的病例，这是在卡泊芬净治疗期间出现的突破性感染。必须考虑到头状马格努斯酵母引起突破性感染的可能性，特别是在接受卡泊芬净治疗系统性真菌感染的免疫抑制患者中。虽然头状马格努斯酵母药敏试验没有明确的折点，但最低抑菌浓度结果对治疗可能有帮助。两性霉素B脂质体复合物加氟胞嘧啶的抗真菌治疗可能对由头状马格努斯酵母引起的感染有效。
