Gurrieri Francesca, Corbellini Silvia, Piccinelli Giorgio, Turra Alessandro, Morello Enrico, Malagola Michele, Russo Domenico, Caruso Arnaldo, De Francesco Maria Antonia
Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, 25123 Brescia, Italy.
Chair of Hematology, Unit of Blood Diseases and Stem Cells Transplantation, University of Brescia-ASST Spedali Civili, 25123 Brescia, Italy.
Vaccines (Basel). 2021 Nov 6;9(11):1289. doi: 10.3390/vaccines9111289.
is an arthroconidial yeast, found principally in the environment, even if it belongs also to the normal microbial flora that colonize human subjects. This yeast is increasingly associated with invasive infections in hematological patients, in particular in those affected by acute leukemia. An important risk factor that predisposes to this infection is the profound neutropenia present in such immunocompromised patients. spp. were found resistant to both echinocandins and fluconazole so the treatment is often difficult. Here, we report two cases of sepsis in two patients with acute leukemia. All of them had fatal events, due to the worsening of their clinical condition. An early diagnosis and appropriate management of these pathogens is important in consideration of the poor prognosis associated to these fungal invasive infections.
是一种关节孢子酵母菌，主要存在于环境中，即便它也属于定植于人类的正常微生物群。这种酵母菌越来越多地与血液学患者的侵袭性感染相关，尤其是急性白血病患者。导致这种感染的一个重要危险因素是此类免疫功能低下患者存在的严重中性粒细胞减少。发现 种对棘白菌素和氟康唑均耐药，因此治疗往往困难。在此，我们报告两例急性白血病患者发生败血症的病例。他们均出现致命事件，原因是临床状况恶化。鉴于这些真菌侵袭性感染预后不佳，对这些病原体进行早期诊断和适当管理很重要。
