Ye Dan, Li Shuwen, Ding Yi, Ma Zhenqin, He Rongxia
The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Department of Obstetrics, Lanzhou University Second Hospital, Lanzhou, China.
Front Cardiovasc Med. 2023 Oct 6;10:1251304. doi: 10.3389/fcvm.2023.1251304. eCollection 2023.
Pre-eclampsia (PE) is a severe pregnancy complication. Thrombocytopenia and platelet dysfunction are common hematology disorders in PE. Previous studies considered mean platelet volume (MPV), a functional marker of platelets, as a potentially useful predictor for the diagnosis of PE.
PubMed, China Biomedical Literature Database, Chinese National Knowledge Infrastructure, Embase, Wanfang, VIP, and Cochrane Library databases were searched to gather diagnostic trials evaluating the diagnosis of PE using MPV, from their inception to 13 March 2023. We also searched Google Scholar and Baidu.
A total of 22 studies from 20 articles were found. The pooled diagnostic accuracy of the MPV for PE recognition was as follows: sensitivity (SEN) 0.676 [95% confidence interval (CI) (0.658-0.694)], specificity (SPE) 0.710 [95% CI (0.703-0.717)], and diagnostic odds ratio (DOR) 7.012 [95% CI (4.226-11.636)], and the SROC-AUC and Q* indices were 0.7889 and 0.7262, respectively. The pooled SEN, SPE, and DOR of the diagnostic accuracy of MPV for PE before 16 weeks of gestation were 0.707 [95% CI (0.670-0.743)], 0.639 [95% CI (0.611-0.667)], and 4.026 [95% CI (2.727-5.943)], and the SROC-AUC and Q* indices were 0.7278 and 0.6753, respectively. For the interval of truncation values between 9 and 10 fl, the SROC-AUC and Q* indices for MPV were 0.8856 and 0.8162, respectively.
Available evidence suggests that MPV has a moderate predictive and diagnostic value for PE, particularly in diagnosing after 20 weeks of gestation. The diagnostic accuracy is higher when the MPV cut-off falls between 9 and 10 fl. The sensitivity of MPV alone in diagnosing PE is not high, and the combination of other markers for predictive diagnosis may better differentiate PE.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425154, identifier: CRD42023425154.
子痫前期（PE）是一种严重的妊娠并发症。血小板减少和血小板功能障碍是PE常见的血液学紊乱。既往研究认为平均血小板体积（MPV）作为血小板的功能标志物，可能是诊断PE的有用预测指标。
检索PubMed、中国生物医学文献数据库、中国知网、Embase、万方、维普和Cochrane图书馆数据库，收集从建库至2023年3月13日评估使用MPV诊断PE的诊断试验。我们还检索了谷歌学术和百度。
共纳入20篇文章中的22项研究。MPV用于识别PE的合并诊断准确性如下：敏感度（SEN）0.676 [95%置信区间（CI）（0.658 - 0.694）]，特异度（SPE）0.710 [95% CI（0.703 - 0.717）]，诊断比值比（DOR）7.012 [95% CI（4.226 - 11.636）]，SROC-AUC和Q指数分别为0.7889和0.7262。妊娠16周前MPV诊断PE的合并SEN、SPE和DOR分别为0.707 [95% CI（0.670 - 0.743）]、0.639 [95% CI（0.611 - 0.667）]和4.026 [95% CI（2.727 - 5.943）]，SROC-AUC和Q指数分别为0.7278和0.6753。截断值区间在9至10 fl时，MPV的SROC-AUC和Q*指数分别为0.8856和0.8162。
现有证据表明，MPV对PE具有中等预测和诊断价值，尤其在妊娠20周后诊断时。当MPV截断值在9至10 fl之间时诊断准确性更高。单独使用MPV诊断PE的敏感度不高，联合其他标志物进行预测诊断可能能更好地区分PE。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425154，标识符：CRD42023425154。
