Zouache Moussa A, Faust Caitlin D, Silvestri Vittorio, Akafo Stephen, Lartey Seth, Mehta Rajnikant, Carroll Joseph, Silvestri Giuliana, Hageman Gregory S, Amoaku Winfried M
Sharon Eccles Steele Center for Translational Medicine, John A. Moran Eye Center, Department of Ophthalmology & Visual Sciences, University of Utah, Salt Lake City, Utah.
NICRN, Belfast Health and Social Care Trust, Belfast, UK.
Ophthalmol Sci. 2023 Aug 21;4(2):100386. doi: 10.1016/j.xops.2023.100386. eCollection 2024 Mar-Apr.
To evaluate the thickness of the macular retina and central choroid in an indigenous population from Ghana, Africa and to compare them with those measured among individuals with European or African ancestry.
Cross-sectional study, systematic review, and meta-analyses.
Forty-two healthy Ghanaians, 37 healthy individuals with European ancestry, and an additional 1427 healthy subjects with African ancestry from previously published studies.
Macular retinal thickness in the fovea, parafovea, and perifovea and central choroidal thickness were extracted from OCT volume scans. Associations with ethnicity, age, and sex were assessed using mixed-effect regression models. Monte Carlo simulations were performed to determine the sensitivity of significant associations to additional potential confounders. Pooled estimates of retinal thickness among other groups with African ancestry were generated through systematic review and meta-analyses.
Macular retinal thickness and central choroidal thickness and their association with ethnicity, age, and sex.
When adjusted for age and sex, the macular retina and central choroid of Ghanaians are significantly thinner as compared with subjects with European ancestry ( < 0.001). A reduction in retinal and choroidal thickness is observed with age, although this effect is independent of ethnicity. Meta-analyses indicate that retinal thickness among Ghanaians differs markedly from that of African Americans and other previously reported indigenous African populations.
The thickness of the retina among Ghanaians differs not only from those measured among individuals with European ancestry, but also from those obtained from African Americans. Normative retinal and choroidal parameters determined among individuals with African or European ancestry may not be sufficient to describe indigenous African populations.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
评估非洲加纳本土人群黄斑视网膜和中央脉络膜的厚度，并将其与欧洲或非洲血统个体的测量结果进行比较。
横断面研究、系统评价和荟萃分析。
42名健康加纳人、37名健康欧洲血统个体，以及先前发表研究中的另外1427名健康非洲血统受试者。
从光学相干断层扫描（OCT）容积扫描中提取中央凹、旁中央凹和周边凹的黄斑视网膜厚度以及中央脉络膜厚度。使用混合效应回归模型评估与种族、年龄和性别的关联。进行蒙特卡罗模拟以确定显著关联对其他潜在混杂因素的敏感性。通过系统评价和荟萃分析得出其他非洲血统人群视网膜厚度的合并估计值。
黄斑视网膜厚度、中央脉络膜厚度及其与种族、年龄和性别的关联。
在调整年龄和性别后，加纳人的黄斑视网膜和中央脉络膜比欧洲血统受试者明显更薄（<0.001）。随着年龄增长，视网膜和脉络膜厚度会降低，尽管这种影响与种族无关。荟萃分析表明，加纳人的视网膜厚度与非裔美国人和其他先前报道的非洲本土人群有显著差异。
加纳人的视网膜厚度不仅与欧洲血统个体不同，也与非裔美国人不同。在非洲或欧洲血统个体中确定的视网膜和脉络膜标准参数可能不足以描述非洲本土人群。
本文末尾的脚注和披露中可能会找到专有或商业披露信息。
