超广角光学相干断层扫描血管造影在中国人群中对脉络膜涡静脉引流系统的成像分析

Profiles of Choroidal Vortex Vein Drainage System Using Ultra-Widefield OCT Angiography in a Chinese Population.

作者信息

Luo Zhonghua, Li Zhenping, Yu Yuefeng, Lu Yan, Du Yangyang, Xiang Xiaolan, Lin Caijuan, Xu Kun, Xu Yue, Huang Jingjing, Yu Shanshan, Lan Yuqing, Liang Xiaoling

机构信息

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.

Department of Ophthalmology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

出版信息

Ophthalmol Sci. 2025 Mar 15;5(4):100768. doi: 10.1016/j.xops.2025.100768. eCollection 2025 Jul-Aug.

DOI:10.1016/j.xops.2025.100768

PMID:40296986

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12036039/

Abstract

PURPOSE

To develop a normative profile for choroidal vortex vein systems based on ultra-widefield OCT angiography (UWF-OCTA) in a healthy Chinese population.

DESIGN

A cross-sectional, multicenter study.

PARTICIPANTS

A total of 515 eyes of 515 Chinese adults (515 healthy eyes) aged ≥20 years were recruited from the Choroidal Vortex Vein System Study.

METHODS

All participants underwent comprehensive ophthalmic examinations. The 2-dimensional and 3-dimensional choroidal parameters of the vortex vein system were measured in each vortex vein drainage quadrant (24 × 20 mm scan mode; central, superotemporal [ST], superonasal [SN], inferonasal [IN], and inferotemporal [IT] quadrants) using a UWF-OCTA device. The normative profile examined the choroidal parameters' fifth and 95th percentile values. The associations of ocular and systemic factors with choroidal parameters were investigated using multivariable linear regression to account for the correlation.

MAIN OUTCOME MEASURES

Choroidal thickness, choroidal vascularity index (CVI), choroidal vascular volume (CVV), and choroidal stromal volume (CSV).

RESULTS

The fifth and 95th percentile values of the choroidal parameter dataset for the peripheral choroidal vortex vein system were set. The mean values of the peripheral choroidal vortex vein system parameters (choroidal thickness, CVI, CVV, and CSV) decreased with age, with a significant decline after 50 years. An association was observed between an increased axial length elongation and a thinner choroid layer in the macular region and the ST drainage system (all < 0.01). The CVI was significantly correlated with gender in the ST vortex vein drainage system (coefficient: -1.02, = 0.04).

CONCLUSIONS

We report a normative choroidal parameter dataset for the peripheral choroidal vortex vein system in a large Chinese cohort. Choroidal vessels and stroma in vortex vein drainage systems decrease with age, more remarkably after the age of 50 years.

FINANCIAL DISCLOSURES

The author(s) have no proprietary or commercial interest in any materials discussed in this article.

摘要

目的

基于超广角光学相干断层扫描血管造影（UWF-OCTA）技术，建立中国健康人群脉络膜涡静脉系统的正常参考值。

设计

一项横断面、多中心研究。

参与者

从脉络膜涡静脉系统研究中招募了515名年龄≥20岁的中国成年人的515只眼睛（515只健康眼睛）。

方法

所有参与者均接受了全面的眼科检查。使用UWF-OCTA设备在每个涡静脉引流象限（24×20毫米扫描模式；中央、颞上[ST]、鼻上[SN]、鼻下[IN]和颞下[IT]象限）测量涡静脉系统的二维和三维脉络膜参数。正常参考值检查了脉络膜参数的第5和第95百分位数。使用多变量线性回归研究眼和全身因素与脉络膜参数的关联，以考虑相关性。

主要观察指标

脉络膜厚度、脉络膜血管指数（CVI）、脉络膜血管体积（CVV）和脉络膜基质体积（CSV）。

结果

设定了周边脉络膜涡静脉系统脉络膜参数数据集的第5和第95百分位数。周边脉络膜涡静脉系统参数（脉络膜厚度、CVI、CVV和CSV）的平均值随年龄增长而降低，50岁后显著下降。观察到轴长增加与黄斑区和ST引流系统中脉络膜层变薄之间存在关联（均P<0.01）。在ST涡静脉引流系统中，CVI与性别显著相关（系数：-1.02，P=0.04）。