在英国2019冠状病毒病大流行的野生型、德尔塔和奥密克戎毒株流行期间，对献血后出现呼吸道症状的献血者进行调查。

Investigating Blood Donors With Postdonation Respiratory Tract Symptoms During the Wild-Type, Delta, and Omicron Waves of the Coronavirus Disease 2019 Pandemic in England.

作者信息

Gates Shannah, Ijaz Samreen, Baklan Hatice, Washington Charlotte, Brailsford Su, Zambon Maria, Harvala Heli

机构信息

Microbiology Services, NHS Blood and Transplant, London, United Kingdom.

Virus Reference Department, United Kingdom Health Security Agency, London, United Kingdom.

出版信息

Open Forum Infect Dis. 2023 Oct 5;10(10):ofad499. doi: 10.1093/ofid/ofad499. eCollection 2023 Oct.

DOI:10.1093/ofid/ofad499

PMID:37869407

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10590102/

Abstract

BACKGROUND

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been shown to be detectable in blood from infected individuals. Though RNAemia frequencies are typically low, the presence of potentially infectious virus potentially poses a transmission risk during blood transfusion.

METHODS

Archived plasma samples were collected from blood donors who later reported possible SARS-CoV-2 infection with the wild-type strain, Delta variant, or Omicron variant. This was based on either symptom onset or a positive test within 2 weeks from their donation. Donations were tested for SARS-CoV-2 RNA, and information on symptoms and testing results were gathered during postdonation interview.

RESULTS

Of 518 archived plasma samples tested, 19 (3.7%) were found to have detectable levels of SARS-CoV-2 RNA. SARS-CoV-2 RNA was detected in donors who donated during the Delta (10/141 [7.1%]) and Omicron (9/162 [5.6%]) waves. SARS-CoV-2 RNA was not detected in donors who donated during the wild-type wave (0/215). Seventeen of 19 RNAemic donors reported symptom onset or a positive test within 2 days of donating. SARS-CoV-2 RNA was detected in asymptomatic or presymptomatic blood donors.

CONCLUSIONS

Despite RNAemia being correlated with SARS-CoV-2 disease severity, RNAemia was detected in asymptomatic or presymptomatic blood donors.

摘要

背景

严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染已被证明在受感染个体的血液中可检测到。尽管病毒血症的发生率通常较低，但潜在感染性病毒的存在可能在输血过程中带来传播风险。

方法

从后来报告感染野生型毒株、德尔塔变种或奥密克戎变种的SARS-CoV-2的献血者中收集存档血浆样本。这是基于症状出现或献血后2周内检测呈阳性。对献血样本进行SARS-CoV-2 RNA检测，并在献血后访谈中收集症状和检测结果信息。

结果

在检测的518份存档血浆样本中，19份（3.7%）被发现具有可检测水平的SARS-CoV-2 RNA。在德尔塔（10/141 [7.1%]）和奥密克戎（9/162 [5.6%]）疫情期间献血的献血者中检测到SARS-CoV-2 RNA。在野生型疫情期间献血的献血者中未检测到SARS-CoV-2 RNA（0/215）。19名病毒血症献血者中有17名在献血后2天内报告症状出现或检测呈阳性。在无症状或症状前献血者中检测到SARS-CoV-2 RNA。