Department of Psychiatry, Elazığ Fethi Sekin City Hospital, Elazığ, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Oct;27(5 Suppl):101-108. doi: 10.26355/eurrev_202310_34078.
Bipolar disorder (manic episode) is an essential psychiatric disorder with unknown etiology, in which inflammation is considered to play a role. Klotho and FGF-23 are known to be associated with inflammation. Therefore, this study aimed to determine the link between Klotho and FGF-23 levels and bipolar disorder.
In this study, 42 men with BD and 41 healthy controls were enrolled, followed up, and/or treated at the High-Security Forensic Psychiatry Clinic. Sociodemographic data form, Young Mania Rating Scale, and Hamilton Depression Rating Scale were applied to all participants.
Klotho and FGF-23 levels were significantly increased in patients with BD manic episodes. There was no correlation between Klotho and FGF-23 levels and clinical parameters. For Klotho and FGF-23, cutoff values of 69 and 1,646 yielded 67.4% sensitivity and 72.1% specificity and 81.4% sensitivity and 51.2% specificity, respectively.
Klotho and FGF-23 may play critical roles in the etiopathology of manic episodes and are potential candidate biomarkers for bipolar disorder. This relationship might contribute to the etiopathogenesis of the disease and determine its treatment. Anti-Klotho and anti-FGF-23 administration may be a future treatment for controlling the course of the disease.
双相情感障碍（躁狂发作）是一种病因不明的重要精神障碍，炎症被认为在其中起作用。Klotho 和 FGF-23 已知与炎症有关。因此，本研究旨在确定 Klotho 和 FGF-23 水平与双相情感障碍之间的联系。
本研究纳入了 42 名男性 BD 患者和 41 名健康对照者，在高安全性法医精神病诊所对他们进行了随访和/或治疗。所有参与者均接受了社会人口统计学数据表格、Young 躁狂评定量表和汉密尔顿抑郁评定量表的评估。
BD 躁狂发作患者的 Klotho 和 FGF-23 水平显著升高。Klotho 和 FGF-23 水平与临床参数之间无相关性。对于 Klotho 和 FGF-23，截断值分别为 69 和 1,646 时，灵敏度分别为 67.4%和 81.4%，特异性分别为 72.1%和 51.2%。
Klotho 和 FGF-23 可能在躁狂发作的病因学中起关键作用，是双相情感障碍的潜在候选生物标志物。这种关系可能有助于疾病的病因学，并决定其治疗方法。抗 Klotho 和抗 FGF-23 治疗可能是控制疾病进程的未来治疗方法。
