Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Av. Alfredo Balena, 190, Room 281, Santa Efigênia, Belo Horizonte, 30130-100, Brazil.
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais (UFMG), Av. Alfredo Balena, 190, Room 281, Santa Efigênia, Belo Horizonte, 30130-100, Brazil; Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, 1941 East Road, Suite 3140, Houston, 77054, USA.
J Psychiatr Res. 2017 Dec;95:80-83. doi: 10.1016/j.jpsychires.2017.08.007. Epub 2017 Aug 11.
Although accelerated aging profile has been described in bipolar disorder (BD), the biology linking BD and aging is still largely unknown. Reduced levels and/or activity of a protein named Klotho is associated with decreased life span, premature aging and occurrence of age-related diseases. Therefore, this study was designed to evaluate plasma levels of Klotho in BD patients and controls.
Forty patients with type 1 BD and 30 controls were enrolled in this study. After clinical evaluation, peripheral blood samples were drawn and plasma levels of Klotho were measured using enzyme-linked immunosorbent assay.
Patients with BD and controls presented similar age and sex distribution. The mean ± SD length of illness was 24.00 ± 12.75 years. BD patients presented increased frequency of clinical comorbidities in comparison with controls, mainly arterial hypertension, diabetes mellitus, and hypothyroidism. Both patients with BD in remission and in mania exhibited increased plasma levels of Klotho in comparison with controls. There was no significant difference between patients in mania and patients in remission regarding the levels of Klotho.
Klotho-related pathway is altered in BD. Contrary to our original hypothesis, our sample of patients with BD presented increased plasma levels of Klotho in comparison with controls. Elevated levels of Klotho in long-term BD patients may be associated with the disorder progression. Further studies are needed to better understand the role of Klotho in BD and other mood disorders.
尽管双相情感障碍（BD）存在加速衰老的特征，但将 BD 与衰老联系起来的生物学机制仍知之甚少。一种名为 Klotho 的蛋白质的水平降低和/或活性降低与寿命缩短、过早衰老以及与年龄相关的疾病的发生有关。因此，本研究旨在评估 BD 患者和对照组的血浆 Klotho 水平。
本研究纳入了 40 名 1 型 BD 患者和 30 名对照组。在临床评估后，抽取外周血样本，并用酶联免疫吸附试验测量 Klotho 的血浆水平。
BD 患者和对照组的年龄和性别分布相似。平均病程为 24.00 ± 12.75 年。BD 患者比对照组有更高的临床合并症频率，主要是高血压、糖尿病和甲状腺功能减退。与对照组相比，缓解期和躁狂期的 BD 患者的血浆 Klotho 水平均升高。躁狂期和缓解期患者的 Klotho 水平之间没有显著差异。
BD 患者的 Klotho 相关通路发生改变。与我们的原始假设相反，我们的 BD 患者样本的血浆 Klotho 水平与对照组相比升高。长期 BD 患者 Klotho 水平升高可能与疾病进展有关。需要进一步的研究来更好地理解 Klotho 在 BD 和其他心境障碍中的作用。
