Multidisciplinary Institute for Health, Federal University of Bahia, Salvador, Brazil.
State University of de Santa Cruz, Ilhéus, Brazil.
Epidemiol Infect. 2023 Oct 23;151:e196. doi: 10.1017/S095026882300170X.
Adolescent men who have sex with men (AMSM) and transgender women (ATGW) enrolled as part of the PrEP1519 study between April 2019 and February 2021 in Salvador were tested for (NG) and (CT) infections.We performed real-time polymerase chain reaction using oropharyngeal, anal, and urethral swabs; assessed factors associated with NG and CT infections using multivariable Poisson regression analysis with robust variance; and estimated the prevalence ratios (PRs) and 95% confidence intervals (95% CIs). In total, 246 participants were included in the analyses (median age: 18.8; IQR: 18.2-19.4 years). The overall oropharyngeal, anal, and urethral prevalence rates of NG were 17.9%, 9.4%, 7.6%, and 1.9%, respectively. For CT, the overall, oropharyngeal, anal, and urethral prevalence rates were 5.9%, 1.2%, 2.4%, and 1.9%, respectively. A low level of education, clinical suspicion of STI (and coinfection with were associated with NG infection. The prevalence of NG and CT, especially extragenital infections, was high in AMSM and ATGW. These findings highlight the need for testing samples from multiple anatomical sites among adolescents at a higher risk of STI acquisition, implementation of school-based strategies, provision of sexual health education, and reduction in barriers to care.
2019 年 4 月至 2021 年 2 月期间，在巴西萨尔瓦多参加 PrEP1519 研究的男男性行为者（MSM）和跨性别女性（TGW）青少年接受了针对淋病奈瑟菌（NG）和沙眼衣原体（CT）感染的检测。我们使用咽拭子、肛拭子和尿道拭子进行实时聚合酶链反应；使用多变量泊松回归分析和稳健方差评估与 NG 和 CT 感染相关的因素；并估计患病率比（PR）和 95%置信区间（95%CI）。共有 246 名参与者纳入分析（中位数年龄：18.8 岁；IQR：18.2-19.4 岁）。NG 的总口咽、肛门和尿道患病率分别为 17.9%、9.4%、7.6%和 1.9%。对于 CT，总患病率、口咽、肛门和尿道患病率分别为 5.9%、1.2%、2.4%和 1.9%。受教育程度低、性传播感染（STI）的临床怀疑以及合并感染与 NG 感染相关。MSM 和 TGW 中 NG 和 CT 的流行率（尤其是外生殖器感染）较高。这些发现强调了需要对性传播感染获得风险较高的青少年进行多个解剖部位的样本检测，实施基于学校的策略，提供性健康教育，并减少获得护理的障碍。
