Willer J C, Dehen H, Cambier J
Rev Neurol (Paris). 1986;142(4):303-7.
Both thresholds of nociceptive flexion reflex and pain sensation were studied in 6 normal subjects and in 6 patients with typical thalamic pain. In these patients, on the painful side, these thresholds were found increased (98 p. 100; 89 p. 100 respectively) compared to the normal side. Values obtained in this latter did not significantly differ from those observed in normal subjects. After 8 days of indalpine treatment, the nociceptive reflex threshold was furthered increased in the painful side while the pain threshold was not modified by this drug. In the normal side, changes observed after indalpine were similar to that obtained in normal subjects. All the indalpine-induced modifications were reversed by naloxone in both patients and normals. These results are discussed in the context of the possible mechanisms of thalamic hyperpathia.
对6名正常受试者和6名典型丘脑痛患者的伤害性屈曲反射阈值和痛觉阈值进行了研究。在这些患者中，患侧的这些阈值与正常侧相比有所升高（分别为98%和89%）。在正常侧获得的值与在正常受试者中观察到的值没有显著差异。茚达品治疗8天后，患侧的伤害性反射阈值进一步升高，而痛觉阈值未被该药物改变。在正常侧，茚达品治疗后观察到的变化与在正常受试者中获得的变化相似。在患者和正常人中，纳洛酮均可逆转茚达品引起的所有变化。在丘脑性痛觉过敏的可能机制背景下对这些结果进行了讨论。
