Guieu R, Pouget J, Serratrice G
Clinique des Maladies du Système Nerveux et de l'Appareil Locomoteur, CHU Timone, Marseille.
Rev Neurol (Paris). 1992;148(10):641-4.
It has now become possible to measure pain thresholds in man by the threshold or amplitude of the leg flexion nociceptive reflex (RIII reflex). These parameters accurately reflect the pain levels perceived by the patients. The aim of the present study was to assess pain thresholds in Parkinsonian patients, using the RIII reflex. Painful phenomena are often mentioned in Parkinson disease, but the perceived pain threshold level can be difficult to assess because of the depressive symptoms which are often associated with Parkinson disease. In 8 cases out of 10, the pain threshold was found to be higher in patients with Parkinson disease than in a control population of the same age: in 2 cases, naloxone injection led to recovery of the normal pain threshold level.
现在已经可以通过腿部屈曲伤害性反射（RIII反射）的阈值或幅度来测量人类的疼痛阈值。这些参数准确反映了患者所感知的疼痛程度。本研究的目的是使用RIII反射评估帕金森病患者的疼痛阈值。帕金森病中经常提到疼痛现象，但由于帕金森病常伴有抑郁症状，因此很难评估所感知的疼痛阈值水平。在10例患者中有8例，发现帕金森病患者的疼痛阈值高于同年龄对照组：在2例患者中，注射纳洛酮后疼痛阈值恢复到正常水平。
