Fabris F, Casonato A, Randi M L, Luzzatto G, Girolami A
Scand J Haematol. 1986 Sep;37(3):215-20. doi: 10.1111/j.1600-0609.1986.tb02300.x.
We have investigated serum platelet bindable IgG(SPBIgG) and platelet-associated IgG(PAIgG) in patients with immune thrombocytopenia (IT) to ascertain the significance of the larger amounts of PAIgG reported both in normals and in patients using homogenized (Total:T-PAIgG) instead of intact platelets (Surface:S-PAIgG). 12 patients, during active immune thrombocytopenia (A-IT), and 18 patients in steroid-induced remission (S-IT), were studied. As control we considered 20 patients with non-immune thrombocytopenia (N-IT) and 29 subjects with normal platelet count. The average positivity of SPBIgG was 41% with a higher percentage in A-IT (66%) than in S-IT (16%). The results of PAIgG also indicate a different behaviour in A-IT and S-IT of surface and cytoplasmatic pools. During A-IT both pools are enhanced with prevalence towards the surface one (S-PAIgG). On the contrary, during steroid-induced remission, despite the normal amount of the S-PAIgG present the internal pool still increases, indicating a steady-state of IT and the possible existence of a platelet phagocytic activity.
我们研究了免疫性血小板减少症（IT）患者的血清血小板可结合IgG（SPBIgG）和血小板相关IgG（PAIgG），以确定在正常人和患者中使用匀浆血小板（总量：T - PAIgG）而非完整血小板（表面：S - PAIgG）时报告的较高水平PAIgG的意义。研究了12例处于免疫性血小板减少症活动期（A - IT）的患者和18例处于类固醇诱导缓解期（S - IT）的患者。作为对照，我们纳入了20例非免疫性血小板减少症（N - IT）患者和29例血小板计数正常的受试者。SPBIgG的平均阳性率为41%，A - IT组（66%）高于S - IT组（16%）。PAIgG的结果也表明，表面池和细胞质池在A - IT和S - IT中的表现不同。在A - IT期间，两个池均增强，且以表面池（S - PAIgG）为主。相反，在类固醇诱导缓解期，尽管表面S - PAIgG量正常，但内部池仍增加，这表明IT处于稳定状态，并且可能存在血小板吞噬活性。
